Polyautoimmunity in Sjogren Syndrome

被引：49

作者：

Anaya, Juan-Manuel ^{[1
]}

Rojas-Villarraga, Adriana ^{[1
]}

Mantilla, Ruben D. ^{[1
]}

Arcos-Burgos, Mauricio ^{[2
]}

Camilo Sarmiento-Monroy, Juan ^{[1
]}

机构：

[1] Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res CREA, Carrera 26 63B-51, Bogota 111221, Colombia

[2] Australian Natl Univ, Genom & Predict Med, Genome Biol Dept, John Curtin Sch Med Res,ANU Coll Med Biol & Envir, Garrand Rd, Canberra, ACT 2600, Australia

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2016年 / 42卷 / 03期

关键词：

Sjogren syndrome; Polyautoimmunity; Autoimmune tautology; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CYCLIC CITRULLINATED PEPTIDE; RHEUMATOID-ARTHRITIS; CLASSIFICATION CRITERIA; CLINICAL MANIFESTATIONS; HASHIMOTO THYROIDITIS; LIVER INVOLVEMENT; SICCA SYMPTOMS; AUTOIMMUNE; DISEASE;

D O I：

10.1016/j.rdc.2016.03.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polyautoimmunity is defined as the presence of more than one well-defined autoimmune disease (AD) in a single patient. Polyautoimmunity is a frequent condition in Sjogren syndrome (SS) and follows a grouping pattern. The most frequent ADs observed in SS are autoimmune thyroid disease, rheumatoid arthritis, and systemic lupus erythematosus. Main factors associated with polyautoimmunity in SS are tobacco smoking and some genetic variants. The study of polyautoimmunity provides important clues for elucidating the common mechanisms of autoimmne diseases (ie, the autoimmune tautology).

引用

页码：457 / +

页数：17

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