Increased lysyl oxidase-like 2 associates with a poor prognosis in non-small cell lung cancer

被引：23

作者：

Zhan, Ping ^{[1
,2
]}

Lv, Xiao-Jing ^{[3
]}

Ji, Ya-Nan ^{[4
]}

Xie, Haiyan ^{[1
,2
]}

Yu, Li-Ke ^{[1
,2
]}

机构：

[1] Southeast Univ, Sch Med, Dept Resp Med, Nanjing Chest Hosp, Nanjing 210029, Jiangsu, Peoples R China

[2] Clin Ctr Nanjing Resp Dis & Imaging, Nanjing 210029, Jiangsu, Peoples R China

[3] Nanjing Univ Tradit Chinese Med, Affiliated Jiangsu Prov Hosp Tradit Chinese Med, Dept Resp Med, Nanjing 210029, Jiangsu, Peoples R China

[4] Nanjing Univ Tradit Chinese Med, Affiliated Jiangsu Prov Hosp Tradit Chinese Med, Nanjing 210029, Jiangsu, Peoples R China

来源：

CLINICAL RESPIRATORY JOURNAL | 2018年 / 12卷 / 02期

关键词：

lysyl oxidase-like 2; metastasis; non-small cell lung cancer; prognosis; PROMOTES MIGRATION; GASTRIC-CANCER; EXPRESSION; LOXL2; PROGRESSION; CARCINOMA; SURVIVAL; LYSYL-OXIDASE-LIKE-2; FIBROBLASTS; METASTASIS;

D O I：

10.1111/crj.12584

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

BackgroundLysyl oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family and is associated with invasiveness and metastasis in breast cancer. However, its relevance in non-small cell lung cancer (NSCLC) remained largely unknown. MethodsLOXL2 protein levels in a cohort of NSCLC and adjacent normal lung tissues were evaluated and analyzed their clinicopathologic and prognostic significance. ResultsIt was found that cytoplasmic and nuclear LOXL2 levels were higher in lung adenocarcinoma (AD) and squamous cell carcinoma (SCC) tissues than in paired adjacent normal tissues. High LOXL2 levels were associated with p-TNM stage, and cytoplasmic, but not nuclear, LOXL2 levels were an independent prognostic factor in lung AD and SCC patients. ConclusionThese results demonstrate that elevated LOXL2 levels are positively associated with poor prognosis in NSCLC patients. LOXL2 might, therefore, serve as a novel prognostic biomarker and potential therapeutic target in NSCLC patients.

引用

页码：712 / 720

页数：9

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