Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells

被引：6

作者：

Wang, Xiao-Yang ^{[1
]}

Gao, Hui ^{[2
]}

Xie, Xiao-Jie ^{[1
]}

Jurhiin, Jirimubatu ^{[3
]}

Zhang, Mu-Zi-He ^{[1
]}

Zhou, Yan-Ping ^{[1
]}

Liu, Rui ^{[1
]}

Ning, Meng ^{[1
]}

Han, Jin ^{[1
]}

Tang, Hai-Feng ^{[4
]}

机构：

[1] Peoples Liberat Army Inst Chinese Med, Dept Pharm, Beijing 100039, Peoples R China

[2] Peoples Liberat Army Inst Organ Transplantat, Beijing 100091, Peoples R China

[3] Inner Mongolia Med Univ, Acad Mongolian Med, Hohhot 010110, Peoples R China

[4] Fourth Mil Med Univ, Inst Mat Med, Sch Pharm, Xian 710032, Shaanxi, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Triterpenoid saponins; Anemone rivularis var. flore-minore; Anti-proliferative activity; HSC-T6; HEPATIC STELLATE CELLS; OLEANANE-TYPE SAPONINS; GLYCOSIDES; RHIZOMES; ROOTS;

D O I：

10.3390/molecules23020491

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five previously undescribed triterpenoid saponins (1-5), along with eight known ones (6-13), were isolated from the whole plants of Anemone rivularis var. flore-minore. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins (3 and 12) were reported from the Anemone genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stellate cells (HSC-T6). Saponins 12 and 13, which possess more monosaccharides than the others, displayed potent anti-proliferative activity, with IC50 values of 18.21 and 15.56 mu M, respectively.

引用

页数：11

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