Synthesis and biological evaluation of 3-(2,4-dichlorophenoxymethyl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents

被引：2
|
作者：
El Shehry, Mohamed F. [1 ]
Abbas, Samir Y. [2 ]
Farrag, Amel M. [3 ]
Fouad, Sawsan A. [4 ]
Ammar, Yousry A. [5 ]
机构：
[1] Natl Res Ctr, Pesticide Chem Dept, Cairo 12622, Egypt
[2] Natl Res Ctr, Organometall & Organometalloid Chem Dept, Cairo, Egypt
[3] Al Azher Univ, Fac Pharm Girls, Pharmaceut Chem Dept, Cairo, Egypt
[4] Al Azhar Univ Girls, Fac Sci, Chem Dept, Cairo, Egypt
[5] Al Azhar Univ, Fac Sci, Chem Dept, Cairo, Egypt
来源：
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2020年 / 17卷 / 10期
关键词：
Pyrazoles; Schiff's bases; Hydrazones; Vinyl derivative; Antitumor agents; PYRAZOLE; ANALOGS; MOIETY;
D O I：
10.1007/s13738-020-01951-w
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Series of novel 3-(2,4-dichlorophenoxymethyl)-1-phenyl-1H-pyrazole derivatives with various substituents at positions 4 and 5 were synthesized. Antitumor activity of all the synthesized compounds was evaluated by using SRB assay on four cell lines: lung carcinoma (A549), human hepatocellular carcinoma (HepG2), colon carcinoma (HCT116) and mammary gland breast cancer (MCF-7) cell lines. Some of the synthesized compounds showed promising activity in comparison with doxorubicin against lung carcinoma cell lines. Incorporating arylidene moiety at position-4 in pyrazole ring improved and displayed strong effect on the cytotoxic activity. Compound9cincorporating 4-chlorophenyl moiety was the most potent toward all tested cell lines.
引用
收藏
页码：2567 / 2575
页数：9
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