Effects of pantoprazole as a HIF-1α inhibitor on human gastric adenocarcinoma sgc-7901 cells

被引：12
作者：
Shen, Y. [1 ]
Wu, Y. [1 ]
Chen, M. [1 ]
Shen, W. [1 ]
Huang, S. [1 ]
Zhang, L. [1 ]
Zou, X. [1 ]
机构：
[1] Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Gastroenterol, Nanjing 210008, Jiangsu, Peoples R China
来源：
NEOPLASMA | 2012年 / 59卷 / 02期
基金：
美国国家科学基金会;
关键词：
gastric cancer; proton pump inhibitors; HIF-1; alpha; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; PROTON PUMP INHIBITOR; TUMOR-GROWTH; FACTOR; 1-ALPHA; CANCER-CELLS; HIF-ALPHA; ANGIOGENESIS; EXPRESSION; PROLIFERATION; APOPTOSIS;
D O I：
10.4149/neo_2012_019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Previously, it has been demonstrated that HIF-1 alpha has close connection with malignant tumor progression, aggressive behavior and prognosis. In addition, proton pump inhibitors (PPIs) have been reported to selectively induce tumor cell apoptosis, thus exerting its anticancer effects. In vitro and in vivo our study revealed that pantoprazole (PPZ) inhibited tumor cells proliferation, induced apoptosis and decreased the expression of HIF-1 alpha protein. In summary, PPZ could suppress tumor growth acting as a HIP-1 alpha protein inhibitor.
引用
收藏
页码：142 / 149
页数：8
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