A case of drug-induced hypersensitivity syndrome showing transient immunosuppression before viral reactivation during treatment for pemphigus foliaceus

被引：15

作者：

Takahashi, H

Tanaka, M

Tanikawa, A

Toyohara, A

Ogo, Y

Morimoto, A

Harato, R

Kobayashi, M

Amagai, M

机构：

[1] Keio Univ, Dept Dermatol, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan

[2] Kitasato Inst Hosp, Tokyo, Japan

[3] OGO Skin Clin, Tokyo, Japan

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2006年 / 31卷 / 01期

关键词：

D O I：

10.1111/j.1365-2230.2005.01913.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Drug-induced hypersensitivity syndrome (DIHS) is one of the most severe drug adverse reactions, with characteristic biphasic symptoms. Reactivation of human herpesvirus-6 (HHV-6) is frequently observed, although the cause of DIHS is still unknown. A patient developed DIHS during treatment with diaminodiphenylsulphone for pemphigus foliaceus. The number of lymphocytes in his peripheral blood, and titres of serum total IgG and IgM and anti-desmoglein1 antibody transiently decreased just before reactivation of HHV-6, cytomegalovirus and Epstein-Barr virus. This observation suggests that transient suppression of both cellular and humoral immunity may trigger viral reactivation, which leads to the development of the second phase of DIHS.

引用

页码：33 / 35

页数：3

共 12 条

[1] Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction [J].