MDA5+ D Dermatomyositis Is Associated with Stronger Skin Type I Interferon Transcriptomic Signature with Upregulation of IFN-κ Transcript

被引：39
作者：
Cassius, Charle [1 ,2 ,3 ,4 ]
Amode, Reyhan [1 ,2 ,4 ]
Delord, Marc [5 ]
Battistella, Maxime [1 ,6 ]
Poirot, Justine [1 ]
How-Kit, Alexandre [7 ]
Lepelletier, Clemence [1 ,2 ,4 ]
Jachiet, Marie [2 ,4 ]
de Masson, Adele [1 ,2 ]
Frumholtz, Laure [2 ,4 ]
Cordoliani, Florence [2 ]
Boccara, David [1 ,8 ]
Lehmann-Che, Jacqueline [1 ,9 ]
Wong, Jennifer [9 ]
Dubanchet, Sylvie [1 ]
Alberdi, Antonio Jose [10 ]
Merandet, Marine [1 ]
Bagot, Martine [1 ,2 ]
Bensussan, Armand [1 ]
Bouaziz, Jean-David [1 ,2 ,4 ]
Le Buanec, Helene [1 ]
机构：
[1] Univ Paris, INSERM, U976, HIPI Unit,Inst Rech St Louis, Paris, France
[2] Hop St Louis, AP HP, Dermatol Dept, Paris, France
[3] Catholic Univ Louvain, CHU UCL Namur, Louvain, Belgium
[4] French Soc Dermatol, Study Grp Syst Dis Dermatol, EMSED Etud Malad Syst Dermatol, Paris, France
[5] Ctr Hosp Versailles, Direct Rech Clin & Innovat, Le Chesnay, France
[6] Hop St Louis, AP HP, Pathol Dept, Paris, France
[7] Fdn Jean Dausset CEPH, Lab Genom, Paris, France
[8] Hop St Louis, AP HP, Plast Reconstruct & Cosmet & Burn Surg Unit, Paris, France
[9] Hop St Louis, AP HP, Mol Oncol Unit, Paris, France
[10] Univ Paris, Hop St Louis, Inst Rech St Louis, Technol Core Facil, Paris, France
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2020年 / 140卷 / 06期
关键词：
POLYMYOSITIS; EXPRESSION; BLOOD;
D O I：
10.1016/j.jid.2019.10.020
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
[No abstract available]
引用
收藏
页码：1276 / 1279
页数：4
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  • [1] Dermatomyositis With or Without Anti-Melanoma Differentiation-Associated Gene 5 Antibodies Common Interferon Signature but Distinct NOS2 Expression
    Allenbach, Yves
    Leroux, Gaelle
    Suarez-Calvet, Xavier
    Preusse, Corinna
    Gallardo, Eduard
    Hervier, Baptiste
    Rigolet, Aude
    Hie, Miguel
    Pehl, Debora
    Limal, Nicolas
    Hufnagl, Peter
    Zerbe, Norman
    Meyer, Alain
    Aouizerate, Jessie
    Uzunhan, Yurdagul
    Maisonobe, Thierry
    Goebel, Hans-Hilmar
    Benveniste, Olivier
    Stenzel, Werner
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2016, 186 (03) : 691 - 700
  • [2] Type I interferon pathway in adult and juvenile dermatomyositis
    Baechler, Emily C.
    Bilgic, Hatice
    Reed, Ann M.
    [J]. ARTHRITIS RESEARCH & THERAPY, 2011, 13 (06)
  • [3] Biomarkers in Adult Dermatomyositis: Tools to Help the Diagnosis and Predict the Clinical Outcome
    Cassius, Charles
    Le Buanec, Helene
    Bouaziz, Jean-David
    Amode, Reyhan
    [J]. JOURNAL OF IMMUNOLOGY RESEARCH, 2019, 2019
  • [4] A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients
    Higgs, Brandon W.
    Zhu, Wei
    Morehouse, Chris
    White, Wendy I.
    Brohawn, Philip
    Guo, Xiang
    Rebelatto, Marlon
    Le, Chenxiong
    Amato, Anthony
    Fiorentino, David
    Greenberg, Steven A.
    Drappa, Jorn
    Richman, Laura
    Greth, Warren
    Jallal, Bahija
    Yao, Yihong
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (01) : 256 - 262
  • [5] Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: A concise review with an emphasis on distinctive clinical features
    Kurtzman, Drew J. B.
    Vleugels, Ruth Ann
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018, 78 (04) : 776 - 785
  • [6] Interferon-κ, a novel type I interferon expressed in human keratinocytes
    LaFleur, DW
    Nardelli, B
    Tsareva, T
    Mather, D
    Feng, P
    Semenuk, M
    Taylor, K
    Buergin, M
    Chinchilla, D
    Roshke, V
    Chen, GX
    Ruben, SM
    Pitha, PM
    Coleman, TA
    Moore, PA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (43) : 39765 - 39771
  • [7] Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection
    Li, Shi-fang
    Gong, Mei-jiao
    Zhao, Fu-rong
    Shao, Jun-jun
    Xie, Yin-li
    Zhang, Yong-guang
    Chang, Hui-yun
    [J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 51 (05) : 2377 - 2396
  • [8] Polymyositis and Dermatomyositis: Pathophysiology
    Nagaraju, Kanneboyina
    Lundberg, Ingrid E.
    [J]. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2011, 37 (02) : 159 - +
  • [9] Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa
    Sarkar, Mrinal K.
    Hile, Grace A.
    Tsoi, Lam C.
    Xing, Xianying
    Liu, Jianhua
    Liang, Yun
    Berthier, Celine C.
    Swindell, William R.
    Patrick, Matthew T.
    Shao, Shuai
    Tsou, Pei-Suen
    Uppala, Ranjitha
    Beamer, Maria A.
    Srivastava, Anshika
    Bielas, Stephanie L.
    Harms, Paul W.
    Getsios, Spiro
    Elder, James T.
    Voorhees, John J.
    Gudjonsson, Johann E.
    Kahlenberg, J. Michelle
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 (11) : 1653 - 1664
  • [10] Analysis of IFN-κ expression in pathologic skin conditions:: Downregulation in psoriasis and atopic dermatitis
    Scarponi, C
    Nardelli, B
    Lafleur, DW
    Moore, PA
    Madonna, S
    De Pità, O
    Girolomoni, G
    Albanesi, C
    [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2006, 26 (03) : 133 - 140
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