MDA5+ D Dermatomyositis Is Associated with Stronger Skin Type I Interferon Transcriptomic Signature with Upregulation of IFN-κ Transcript

被引:44
作者
Cassius, Charle [1 ,2 ,3 ,4 ]
Amode, Reyhan [1 ,2 ,4 ]
Delord, Marc [5 ]
Battistella, Maxime [1 ,6 ]
Poirot, Justine [1 ]
How-Kit, Alexandre [7 ]
Lepelletier, Clemence [1 ,2 ,4 ]
Jachiet, Marie [2 ,4 ]
de Masson, Adele [1 ,2 ]
Frumholtz, Laure [2 ,4 ]
Cordoliani, Florence [2 ]
Boccara, David [1 ,8 ]
Lehmann-Che, Jacqueline [1 ,9 ]
Wong, Jennifer [9 ]
Dubanchet, Sylvie [1 ]
Alberdi, Antonio Jose [10 ]
Merandet, Marine [1 ]
Bagot, Martine [1 ,2 ]
Bensussan, Armand [1 ]
Bouaziz, Jean-David [1 ,2 ,4 ]
Le Buanec, Helene [1 ]
机构
[1] Univ Paris, INSERM, U976, HIPI Unit,Inst Rech St Louis, Paris, France
[2] Hop St Louis, AP HP, Dermatol Dept, Paris, France
[3] Catholic Univ Louvain, CHU UCL Namur, Louvain, Belgium
[4] French Soc Dermatol, Study Grp Syst Dis Dermatol, EMSED Etud Malad Syst Dermatol, Paris, France
[5] Ctr Hosp Versailles, Direct Rech Clin & Innovat, Le Chesnay, France
[6] Hop St Louis, AP HP, Pathol Dept, Paris, France
[7] Fdn Jean Dausset CEPH, Lab Genom, Paris, France
[8] Hop St Louis, AP HP, Plast Reconstruct & Cosmet & Burn Surg Unit, Paris, France
[9] Hop St Louis, AP HP, Mol Oncol Unit, Paris, France
[10] Univ Paris, Hop St Louis, Inst Rech St Louis, Technol Core Facil, Paris, France
关键词
POLYMYOSITIS; EXPRESSION; BLOOD;
D O I
10.1016/j.jid.2019.10.020
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
[No abstract available]
引用
收藏
页码:1276 / 1279
页数:4
相关论文
共 15 条
[1]   Dermatomyositis With or Without Anti-Melanoma Differentiation-Associated Gene 5 Antibodies Common Interferon Signature but Distinct NOS2 Expression [J].
Allenbach, Yves ;
Leroux, Gaelle ;
Suarez-Calvet, Xavier ;
Preusse, Corinna ;
Gallardo, Eduard ;
Hervier, Baptiste ;
Rigolet, Aude ;
Hie, Miguel ;
Pehl, Debora ;
Limal, Nicolas ;
Hufnagl, Peter ;
Zerbe, Norman ;
Meyer, Alain ;
Aouizerate, Jessie ;
Uzunhan, Yurdagul ;
Maisonobe, Thierry ;
Goebel, Hans-Hilmar ;
Benveniste, Olivier ;
Stenzel, Werner .
AMERICAN JOURNAL OF PATHOLOGY, 2016, 186 (03) :691-700
[2]   Type I interferon pathway in adult and juvenile dermatomyositis [J].
Baechler, Emily C. ;
Bilgic, Hatice ;
Reed, Ann M. .
ARTHRITIS RESEARCH & THERAPY, 2011, 13 (06)
[3]   Biomarkers in Adult Dermatomyositis: Tools to Help the Diagnosis and Predict the Clinical Outcome [J].
Cassius, Charles ;
Le Buanec, Helene ;
Bouaziz, Jean-David ;
Amode, Reyhan .
JOURNAL OF IMMUNOLOGY RESEARCH, 2019, 2019
[4]   A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients [J].
Higgs, Brandon W. ;
Zhu, Wei ;
Morehouse, Chris ;
White, Wendy I. ;
Brohawn, Philip ;
Guo, Xiang ;
Rebelatto, Marlon ;
Le, Chenxiong ;
Amato, Anthony ;
Fiorentino, David ;
Greenberg, Steven A. ;
Drappa, Jorn ;
Richman, Laura ;
Greth, Warren ;
Jallal, Bahija ;
Yao, Yihong .
ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (01) :256-262
[5]   Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: A concise review with an emphasis on distinctive clinical features [J].
Kurtzman, Drew J. B. ;
Vleugels, Ruth Ann .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018, 78 (04) :776-785
[6]   Interferon-κ, a novel type I interferon expressed in human keratinocytes [J].
LaFleur, DW ;
Nardelli, B ;
Tsareva, T ;
Mather, D ;
Feng, P ;
Semenuk, M ;
Taylor, K ;
Buergin, M ;
Chinchilla, D ;
Roshke, V ;
Chen, GX ;
Ruben, SM ;
Pitha, PM ;
Coleman, TA ;
Moore, PA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (43) :39765-39771
[7]   Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection [J].
Li, Shi-fang ;
Gong, Mei-jiao ;
Zhao, Fu-rong ;
Shao, Jun-jun ;
Xie, Yin-li ;
Zhang, Yong-guang ;
Chang, Hui-yun .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 51 (05) :2377-2396
[8]   Polymyositis and Dermatomyositis: Pathophysiology [J].
Nagaraju, Kanneboyina ;
Lundberg, Ingrid E. .
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2011, 37 (02) :159-+
[9]   Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa [J].
Sarkar, Mrinal K. ;
Hile, Grace A. ;
Tsoi, Lam C. ;
Xing, Xianying ;
Liu, Jianhua ;
Liang, Yun ;
Berthier, Celine C. ;
Swindell, William R. ;
Patrick, Matthew T. ;
Shao, Shuai ;
Tsou, Pei-Suen ;
Uppala, Ranjitha ;
Beamer, Maria A. ;
Srivastava, Anshika ;
Bielas, Stephanie L. ;
Harms, Paul W. ;
Getsios, Spiro ;
Elder, James T. ;
Voorhees, John J. ;
Gudjonsson, Johann E. ;
Kahlenberg, J. Michelle .
ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 (11) :1653-1664
[10]   Analysis of IFN-κ expression in pathologic skin conditions:: Downregulation in psoriasis and atopic dermatitis [J].
Scarponi, C ;
Nardelli, B ;
Lafleur, DW ;
Moore, PA ;
Madonna, S ;
De Pità, O ;
Girolomoni, G ;
Albanesi, C .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2006, 26 (03) :133-140