The Outcome of Allogeneic Hematopoietic Stem Cell Transplants Without Total Body Irradiation in Pediatric Patients With Acute Lymphoblastic Leukemia: Single Centre Experience

被引:16
作者
Hamidieh, Amir [2 ]
Kargar, Mona [1 ]
Jahani, Mohammad [2 ]
Alimoghaddam, Kamran [2 ]
Bahar, Babak [2 ]
Mousavi, Seyed Asadollah [2 ]
Iravani, Masoud [2 ]
Jalali, Arash [2 ]
Jalili, Mahdi [2 ]
Ghavamzadeh, Ardeshir [2 ]
机构
[1] Univ Tehran Med Sci, Fac Pharm, Dept Clin Pharm, Tehran, Iran
[2] Univ Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran
关键词
hematopoietic stem cell transplantation; acute lymphoblastic leukemia; pediatric; BONE-MARROW-TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; TERM-FOLLOW-UP; CONDITIONING REGIMENS; PREPARATIVE REGIMEN; RANDOMIZED-TRIAL; COMPLETE REMISSION; BUSULFAN-CYTOXAN; RENAL TOXICITY; 2ND REMISSION;
D O I
10.1097/MPH.0b013e31824435a1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The most widely accepted conditioning regimen to allogeneic hematopoietic stem cell transplantation consists of total body irradiation, especially in patients affected by acute lymphoblastic leukemia (ALL). In this retrospective study, we report our experience on hematopoietic stem cell transplantation in 44 pediatric patients with acute lymphoblastic leukemia using a non-radiation-based conditioning regimen (busulfan/cyclophosphamide). Median age at transplantation was 12.5 years (range, 4 to 14 y). 39 out of 44 patients received transplants in complete remission. At a median follow-up of 390 days, the probabilities of 3-year disease-free survival and overall survival were 50% and 68%, respectively. Disease status of hematopoietic stem cell transplantation was the only significant variable affecting the overall survival. Acute and chronic graft-versus-host disease occurred in 23 (64%) and 12(18%) patients, respectively. Relapse was significantly higher among patients transplanted in advanced disease status. The results of the study indicate that non-radiation-based preparative regimens can be used in pediatric patients with ALL. However, well-designed comparative trials are needed to better clarify the difference between radiation and non-radiation-based conditioning regimens in pediatric ALL.
引用
收藏
页码:101 / 107
页数:7
相关论文
共 46 条
  • [1] Risk assessment in haematopoietic stem cell transplantation: Conditioning
    Aschan, Johan
    [J]. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2007, 20 (02) : 295 - 310
  • [2] Effects of total-body irradiation on growth, thyroid and pituitary gland in rhesus monkeys
    Bakker, B
    Massa, GG
    van Rijn, AM
    Mearadji, A
    van der Kamp, HJ
    Niemer-Tucker, MMB
    van der Hage, MH
    Broerse, JJ
    Wit, JM
    [J]. RADIOTHERAPY AND ONCOLOGY, 1999, 51 (02) : 187 - 192
  • [3] Cataracts after total body irradiation and bone marrow transplantation in patients with acute leukemia in complete remission: A study of the European Group for Blood and Marrow Transplantation
    Belkacemi, Y
    Labopin, M
    Vernant, JP
    Prentice, HG
    Tichelli, A
    Schattenberg, A
    Boogaerts, MA
    Ernst, P
    Della Volpe, A
    Goldstone, AH
    Jouet, JP
    Verdonck, LF
    Locasciulli, A
    Rio, B
    Ozsahin, M
    Gorin, NC
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 41 (03): : 659 - 668
  • [4] BLAISE D, 1992, BLOOD, V79, P2578
  • [5] Renal toxicity after total body irradiation
    Borg, M
    Hughes, T
    Horvath, N
    Rice, M
    Thomas, AC
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2002, 54 (04): : 1165 - 1173
  • [6] Unrelated donor stem cell transplantation compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission: a matched-pair analysis
    Borgmann, A
    von Stackelberg, A
    Hartmann, R
    Ebell, W
    Klingebiel, T
    Peters, C
    Henze, G
    [J]. BLOOD, 2003, 101 (10) : 3835 - 3839
  • [7] Randomized trial of busulfan vs total body irradiation containing conditioning regimens for children with acute lymphoblastic leukemia:: A Pediatric Blood and Marrow Transplant Consortium study
    Bunin, N
    Aplenc, R
    Kamani, N
    Shaw, K
    Cnaan, A
    Simms, S
    [J]. BONE MARROW TRANSPLANTATION, 2003, 32 (06) : 543 - 548
  • [8] Impact of drug therapy, radiation dose, and dose rate on renal toxicity following bone marrow transplantation
    Cheng, Jonathan C.
    Schultheiss, Timothy E.
    Wong, Jeffrey Y. C.
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2008, 71 (05): : 1436 - 1443
  • [9] MARROW TRANSPLANTATION FOR CHRONIC MYELOID-LEUKEMIA - A RANDOMIZED STUDY COMPARING CYCLOPHOSPHAMIDE AND TOTAL-BODY IRRADIATION WITH BUSULFAN AND CYCLOPHOSPHAMIDE
    CLIFT, RA
    BUCKNER, CD
    THOMAS, ED
    BENSINGER, WI
    BOWDEN, R
    BRYANT, E
    DEEG, HJ
    DONEY, KC
    FISHER, LD
    HANSEN, JA
    MARTIN, P
    MCDONALD, GB
    SANDERS, JE
    SCHOCH, G
    SINGER, J
    STORB, R
    SULLIVAN, KM
    WITHERSPOON, RP
    APPELBAUM, FR
    [J]. BLOOD, 1994, 84 (06) : 2036 - 2043
  • [10] Antileukemic and long-term effects of two regimens with or without TBI in allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia
    Dai, QY
    Souillet, G
    Bertrand, Y
    Galambrun, C
    Bleyzac, N
    Manel, AM
    Bruno, B
    Souillet, AL
    Homole, E
    Pages, MP
    Berlier, P
    David, M
    Berthier, JC
    Massenavette, B
    Contamin, B
    Philippe, N
    [J]. BONE MARROW TRANSPLANTATION, 2004, 34 (08) : 667 - 673