The potential danger of suboptimal antibody responses in COVID-19

被引：373

作者：

Iwasaki, Akiko ^{[1
,2
]}

Yang, Yexin ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2020年 / 20卷 / 06期

关键词：

SARS-COV; INFECTION; VACCINE; NEUTRALIZATION; PROTEIN; CELLS; MICE;

D O I：

10.1038/s41577-020-0321-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Here, Iwasaki and Yang highlight the potential dangers of inducing suboptimal antibody responses to SARS-CoV-2. They stress the need for proper safety evaluation of candidate vaccines for COVID-19. There is a desperate need for effective therapies and vaccines for SARS-CoV-2 to mitigate the growing economic crisis that has ensued from societal lockdown. Vaccines are being developed at an unprecedented speed and are already in clinical trials, without preclinical testing for safety and efficacy. Yet, safety evaluation of candidate vaccines must not be overlooked.

引用

页码：339 / 341

页数：3

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