Expression of co-stimulatory molecules CD80 and CD86 is altered in CD14+HLA-DR+ monocytes from patients with Chagas disease following induction by Trypanosoma cruzi recombinant antigens

被引：9

作者：

de Araujo Soares, Ana Karine ^{[1
]}

Feitosa Neves, Patricia Areias ^{[1
]}

Aureliano de Melo Cavalcanti, Maria da Gloria ^{[2
,3
]}

Marinho, Silvia Martins ^{[2
,3
]}

de Oliveira Junior, Wilson ^{[2
,3
]}

de Souza, Joelma Rodrigues ^{[4
]}

Barros de Lorena, Virginia Maria ^{[1
,3
]}

Gomes, Yara de Miranda ^{[1
,3
]}

机构：

[1] Fundacao Oswaldo Cruz, Ctr Pesquisas Aggeu Magalhaes, Recife, PE, Brazil

[2] Univ Pernambuco, Pronto Socorro Cardiol Pernambuco PROCAPE, Recife, PE, Brazil

[3] Fundacao Oswaldo Cruz, Programa Integrado Doenca Chagas, Rio De Janeiro, RJ, Brazil

[4] Univ Fed Paraiba, Dept Fisiol & Patol, Joao Pessoa, Paraiba, Brazil

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2016年 / 49卷 / 05期

关键词：

Chagas disease; Immune response; Recombinant antigens; INDETERMINATE; CYTOKINES; CELLS;

D O I：

10.1590/0037-8682-0149-2016

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Introduction: The relationships between monocytes and lymphocytes through MHC class II molecules and costimulatory, are of utmost importance for the production of an efficient immune response. In this work, we assessed the expression of surface molecules CD80 and CD86 on CD14(+)HLA-DR+ monocytes from patients with Chagas disease. Methods: The study population consisted of 31 patients with chronic clinical forms of Chagas disease. Patient blood samples were cultured in the presence of recombinant cytoplasmic repetitive antigen (CRA) and flagellar repetitive antigen (FRA). Results: We found considerable differences in the expression profile of surface molecules involved in antigen presentation. Conclusions: CRA and FRA may contribute to host immune response evasion by Trypanozoma cruzi.

引用

页码：632 / 636

页数：5