Uric acid: The oxidant-antioxidant paradox

被引：664

作者：

Sautin, Yuri Y. ^{[1
]}

Johnson, Richard J. ^{[1
]}

机构：

[1] Univ Florida, Dept Med, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32610 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2008年 / 27卷 / 6-7期

关键词：

uric acid; redox homeostasis; metabolic syndrome; cardiovascular disease;

D O I：

10.1080/15257770802138558

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Uric acid, despite being a major antioxidant in the human plasma, both correlates and predicts development of obesity, hypertension, and cardiovascular disease, conditions associated with oxidative stress. While one explanation for this paradox could be that a rise in uric acid represents an attempted protective response by the host, we review the evidence that uric acid may function either as an antioxidant (primarily in plasma) or pro-oxidant (primarily within the cell). We suggest that it is the pro-oxidative effects of uric acid that occur in cardiovascular disease and may have a contributory role in the pathogenesis of these conditions.

引用

页码：608 / 619

页数：12

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