Silencing of foreign DNA in bacteria

被引：86

作者：

Ali, Sabrina S. ^{[1
]}

Xia, Bin ^{[2
]}

Liu, Jun ^{[1
]}

Navarre, William Wiley ^{[1
]}

机构：

[1] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

[2] Peking Univ, Coll Chem & Mol Engn, Sch Life Sci, Beijing NMR Ctr, Beijing 100871, Peoples R China

来源：

CURRENT OPINION IN MICROBIOLOGY | 2012年 / 15卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

PROTEIN H-NS; NUCLEOID-ASSOCIATED PROTEIN; ESCHERICHIA-COLI GENOME; LATERAL GENE-TRANSFER; AT-RICH DNA; PATHOGENICITY ISLANDS; STRUCTURAL BASIS; CURVED DNA; MYCOBACTERIUM-TUBERCULOSIS; OLIGOMERIZATION DOMAIN;

D O I：

10.1016/j.mib.2011.12.014

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Xenogeneic silencing proteins facilitate horizontal gene transfer by silencing expression of AT-rich sequences. By virtue of their activity these proteins serve as. master regulators of a variety of important functions including motility, drug resistance, and virulence. Three families of silencers have been identified to date: the H-NS like proteins et Gram-negative bacteria, the MvaT like proteins of Pseudomonacae, and the Lsr2 proteins of Actinobacteria. Structural and biochemical characterization of these proteins have revealed that they share surprising commonalities in mechanism and function despite extensive divergence in both sequence and structure. Here we discuss the mechanisms that underlie the ability of these proteins to selectively target AT-rich DNA and the contradictory data regarding the mode by which H-NS forms nucleoprotein complexes.

引用

页码：175 / 181

页数：7

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