Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications

被引:7
作者
Tesiye, Maryam Rahimi [1 ]
Gol, Mohammad [2 ,3 ]
Fadardi, Mohammad Rajabi [4 ]
Kani, Seyede Nasim Mousavi [4 ]
Costa, Anna-Maria [2 ]
Ghasemi-Kasman, Maryam [5 ,6 ]
Biagini, Giuseppe [2 ]
机构
[1] Shahid Beheshti Univ, Fac Life Sci & Biotechnol, Tehran 983969411, Iran
[2] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, I-41125 Modena, Italy
[3] Univ Modena & Reggio Emilia, PhD Sch Clin & Expt Med CEM, I-41125 Modena, Italy
[4] Babol Univ Med Sci, Student Res Comm, Babol 4717647745, Iran
[5] Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol 4717647745, Iran
[6] Babol Univ Med Sci, Sch Med Sci, Dept Physiol, Babol 4717647745, Iran
关键词
antiseizure medications; epilepsy; mesenchymal stem cells; UMBILICAL-CORD BLOOD; ADENOSINE-RELEASING CELLS; TEMPORAL-LOBE EPILEPSY; BONE-MARROW; VALPROIC ACID; MONONUCLEAR-CELLS; STROMAL CELLS; RAT MODEL; REVERSIBLE PARKINSONISM; SEIZURE FREQUENCY;
D O I
10.3390/cells11244129
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Epilepsy is a life-threatening neurological disease that affects approximately 70 million people worldwide. Although the vast majority of patients may be successfully managed with currently used antiseizure medication (ASM), the search for alternative therapies is still necessary due to pharmacoresistance in about 30% of patients with epilepsy. Here, we review the effects of ASMs on stem cell treatment when they could be, as expected, co-administered. Indeed, it has been reported that ASMs produce significant effects on the differentiation and determination of stem cell fate. In addition, we discuss more recent findings on mesenchymal stem cells (MSCs) in pre-clinical and clinical investigations. In this regard, their ability to differentiate into various cell types, reach damaged tissues and produce and release biologically active molecules with immunomodulatory/anti-inflammatory and regenerative properties make them a high-potential therapeutic tool to address neuroinflammation in different neurological disorders, including epilepsy. Overall, the characteristics of MSCs to be genetically engineered, in order to replace dysfunctional elements with the aim of restoring normal tissue functioning, suggested that these cells could be good candidates for the treatment of epilepsy refractory to ASMs. Further research is required to understand the potential of stem cell treatment in epileptic patients and its interaction with ASMs.
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页数:29
相关论文
共 158 条
  • [21] Cost-effectiveness of first-line antiepileptic drug treatments in the developing world: A population-level analysis
    Chisholm, D
    [J]. EPILEPSIA, 2005, 46 (05) : 751 - 759
  • [22] Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors
    Cho, HH
    Park, HT
    Kim, YJ
    Bae, YC
    Suh, KT
    Jung, JS
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2005, 96 (03) : 533 - 542
  • [23] Reprogramming of Human Somatic Cells Using Human and Animal Oocytes
    Chung, Young
    Bishop, Colin E.
    Treff, Nathan R.
    Walker, Stephen J.
    Sandler, Vladislav M.
    Becker, Sandy
    Klimanskaya, Irina
    Wun, Wan-Song
    Dunn, Randall
    Hall, Rebecca M.
    Su, Jing
    Lu, Shi-Jiang
    Maserati, Marc
    Choi, Young-Ho
    Scott, Richard
    Atala, Anthony
    Dittman, Ralph
    Lanza, Robert
    [J]. CLONING AND STEM CELLS, 2009, 11 (02) : 213 - 223
  • [24] The Role of Epigenetic Regulation and Pluripotency-Related MicroRNAs in Differentiation of Pancreatic Stem Cells to Beta Cells
    Coskun, Ediz
    Ercin, Merve
    Gezginci-Oktayoglu, Selda
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 119 (01) : 455 - 467
  • [25] Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats
    Costa-Ferro, Zaquer S. M.
    Souza, Bruno S. F.
    Leal, Marcos M. T.
    Kaneto, Carla Martins
    Azevedo, Carine Machado
    da Silva, Igor Campos
    Soares, Milena B. P.
    Ribeiro-dos-Santos, Ricardo
    DaCosta, Jaderson C.
    [J]. NEUROBIOLOGY OF DISEASE, 2012, 46 (02) : 302 - 313
  • [26] Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy
    Costa-Ferro, Zaquer S. M.
    Vitola, Affonso S.
    Pedroso, Michele F.
    Cunha, Fernanda B.
    Xavier, Leder L.
    Machado, Denise C.
    Soares, Milena B. P.
    Ribeiro-dos-Santos, Ricardo
    daCosta, Jaderson C.
    [J]. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2010, 19 (02): : 84 - 92
  • [27] DaCosta JC, 2018, J TISSUE ENG REGEN M, V12, pE648, DOI [10.1002/term.2334, 10.1002/term.2456]
  • [28] DAVIS DS, 1995, KENNEDY INST ETHIC J, V5, P343
  • [29] Transdifferentiation of brain-derived neurotrophic factor (BDNF)-secreting mesenchymal stem cells significantly enhance BDNF secretion and Schwann cell marker proteins
    De la Rosa, Metzere Bierlein
    Sharma, Anup D.
    Mallapragada, Surya K.
    Sakaguchi, Donald S.
    [J]. JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2017, 124 (05) : 572 - 582
  • [30] Intrathecal Injection of Allogenic Bone Marrow-Derived Mesenchymal Stromal Cells in Treatment of Patients with Severe Ischemic Stroke: Study Protocol for a Randomized Controlled Observer-Blinded Trial
    Deng, Lingna
    Peng, Qingxia
    Wang, Hongxuan
    Pan, Jingrui
    Zhou, Ying
    Pan, Kuang
    Li, Jinteng
    Wu, Yanfeng
    Wang, Yidong
    [J]. TRANSLATIONAL STROKE RESEARCH, 2019, 10 (02) : 170 - 177