Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications

被引:7
作者
Tesiye, Maryam Rahimi [1 ]
Gol, Mohammad [2 ,3 ]
Fadardi, Mohammad Rajabi [4 ]
Kani, Seyede Nasim Mousavi [4 ]
Costa, Anna-Maria [2 ]
Ghasemi-Kasman, Maryam [5 ,6 ]
Biagini, Giuseppe [2 ]
机构
[1] Shahid Beheshti Univ, Fac Life Sci & Biotechnol, Tehran 983969411, Iran
[2] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, I-41125 Modena, Italy
[3] Univ Modena & Reggio Emilia, PhD Sch Clin & Expt Med CEM, I-41125 Modena, Italy
[4] Babol Univ Med Sci, Student Res Comm, Babol 4717647745, Iran
[5] Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol 4717647745, Iran
[6] Babol Univ Med Sci, Sch Med Sci, Dept Physiol, Babol 4717647745, Iran
关键词
antiseizure medications; epilepsy; mesenchymal stem cells; UMBILICAL-CORD BLOOD; ADENOSINE-RELEASING CELLS; TEMPORAL-LOBE EPILEPSY; BONE-MARROW; VALPROIC ACID; MONONUCLEAR-CELLS; STROMAL CELLS; RAT MODEL; REVERSIBLE PARKINSONISM; SEIZURE FREQUENCY;
D O I
10.3390/cells11244129
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Epilepsy is a life-threatening neurological disease that affects approximately 70 million people worldwide. Although the vast majority of patients may be successfully managed with currently used antiseizure medication (ASM), the search for alternative therapies is still necessary due to pharmacoresistance in about 30% of patients with epilepsy. Here, we review the effects of ASMs on stem cell treatment when they could be, as expected, co-administered. Indeed, it has been reported that ASMs produce significant effects on the differentiation and determination of stem cell fate. In addition, we discuss more recent findings on mesenchymal stem cells (MSCs) in pre-clinical and clinical investigations. In this regard, their ability to differentiate into various cell types, reach damaged tissues and produce and release biologically active molecules with immunomodulatory/anti-inflammatory and regenerative properties make them a high-potential therapeutic tool to address neuroinflammation in different neurological disorders, including epilepsy. Overall, the characteristics of MSCs to be genetically engineered, in order to replace dysfunctional elements with the aim of restoring normal tissue functioning, suggested that these cells could be good candidates for the treatment of epilepsy refractory to ASMs. Further research is required to understand the potential of stem cell treatment in epileptic patients and its interaction with ASMs.
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页数:29
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