Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy

被引:246
作者
Yuuki, T
Kanda, T
Kimura, Y
Kotajima, N
Tamura, J
Kobayashi, I
Kishi, S
机构
[1] Gunma Univ, Sch Med, Dept Ophthalmol, Maebashi, Gumma 371, Japan
[2] Gunma Univ, Sch Med, Dept Lab Med, Maebashi, Gumma 371, Japan
[3] Gunma Univ, Sch Med, Dept Gen Med, Maebashi, Gumma 371, Japan
关键词
cytokine; retinopathy; interleukin-8; tumor necrosis factor-alpha;
D O I
10.1016/S1056-8727(01)00155-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To determine whether inflammatory cytokines are increased in proliferative diabetic retinopathy. We measured concentrations of interleukin-6, 8 (IL-6, 8) and tumor necrosis factor (TNF)-alpha by enzyme-linked immunosorbent assay (ELISA) in vitreous and serum from 47 patients with proliferative diabetic retinopathy and 21 patients with vitreous noninflammatory retinopathies. Vitreous concentration of IL-6 were 64.7 +/- 12.8 pg/ml in proliferative diabetic retinopathy, much greater(P<.005) than in noninflammatory retinopathy (2.8<plus/minus>4.5 pg/ml). Amounts of IL-8 in vitreous fluid also were greater in proliferative retinopathy than in noninflammatory retinopathy(34.0 +/- 11.5 vs. 6.1 +/-2.0 pg/ml, P<.005). Concentrations of TNIF-<alpha> in vitreous fluid were not statistically different in proliferative retinopathy from those in noninflammatory retinopathy. In sera, concentrations of IL-6 and IL-8 were not different between proliferative and noninflammatory retinopathy. However, serum TNF-alpha was much greater in proliferative retinopathy than in noninflammatory retinopathy (0.81 +/-0.72 vs. 0.09 +/-0.00 pg/ml, P<.001), Elevated TNF-<alpha> in serum then may be diagnostically useful in proliferative diabetic retinopathy. And inflammatory cytokines in vitreous may be pathogenically important in this concentration. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:257 / 259
页数:3
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