Comparison of the Effect of Fentanyl, Sufentanil, Alfentanil and Remifentanil on Cardiovascular Response to Tracheal Intubation in Children

被引:1
|
作者
Mireskandari, Seyed-Mohamed [1 ,2 ]
Abulahrar, Navid [1 ,3 ]
Darabi, Mohamad Esmaeil [1 ,2 ]
Rahimi, Iman [1 ,2 ]
Mohamadi, Fatemeh Haji [1 ,4 ]
Movafegh, Ali [1 ,3 ]
机构
[1] Univ Tehran Med Sci, Dept Anesthesiol & Crit Care, Tehran, Iran
[2] Univ Tehran Med Sci, Bahrami Hosp, Tehran, Iran
[3] Univ Tehran Med Sci, Dr Ali Shariati Hosp, Tehran, Iran
[4] Univ Tehran Med Sci, Amir Alam Hosp, Tehran, Iran
关键词
Intubation; Laryngoscopy; Opioid; Sufentanil; Alfentanil; Fentanyl; Remifentanil; RAPID-SEQUENCE INDUCTION; HEMODYNAMIC-RESPONSE; MUSCLE-RELAXANTS; DOSE-RESPONSE; PROPOFOL; PREMEDICATION; LARYNGOSCOPY; COMBINATION; ANESTHESIA; INFANTS;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: Laryngoscopy and tracheal intubation may cause significant cerebral and systemic hemodynamic responses. Many drugs have been shown to be effective in modifying these hemodynamic responses, including fentanyl, sufentanil, alfentanil and remifentanil. The purpose of the current study was to compare the efficacy of fentanyl, sufentanil, alfentanil and remifentanil on blunting cardiovascular changes during laryngoscopy and intubation in children. Methods: Eighty children, 1-6 years old, classified as American Society of Anesthesiologists physical status I and II who were scheduled for elective surgery with general anesthesia and orotracheal intubation, were enrolled in this randomized and double-blinded study. Patients were randomly assigned into four groups of 20 patients. Group F received fentanyl 1 mu g/kg(-1), group S received sufentanil 0.1 mu g/kg(-1), group A received alfentanil 10 mu g/kg(-1) and group R received remifentanil 1 mu g/kg(-1) intravenously. After establishment of neuromuscular blockade confirmed with a nerve,stimulator, laryngoscppy and orotracheal,intubation were performed 3 min after induction. Hemodynamic variables including systolic and diastolic blood pressure (SAP, DAP) and heart rate (HR) were recorded at base line (before opioid administration), before laryngoscopy and one minute after orotracheal intubation. Findings: The patients' characteristics and laryngoscopy grade were similar in all groups. There was no significant difference in the mean values of SAP, DAP and HR at each measured time between the four groups. There was significant difference in the mean values of SAP, DAP and HR measured over time in each group. Conclusion: The intravenous fentanyl attenuated laryngoscopy-induced SAP, DAP and HR increases better than sufentanil, alfentanil or remifentanil and hemodynamic stability is better preserved, with fentanyl.
引用
收藏
页码:173 / 180
页数:8
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