Vitamin E intake from natural sources and head and neck cancer risk: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium

被引:21
作者
Edefonti, V. [1 ]
Hashibe, M. [2 ,3 ]
Parpinel, M. [4 ]
Ferraroni, M. [1 ]
Turati, F. [5 ]
Serraino, D. [6 ]
Matsuo, K. [7 ]
Olshan, A. F. [8 ]
Zevallos, J. P. [9 ]
Winn, D. M. [10 ]
Moysich, K. [11 ]
Zhang, Z-F [12 ]
Morgenstern, H. [13 ,14 ,15 ]
Levi, F. [16 ]
Kelsey, K. [17 ]
McClean, M. [18 ]
Bosetti, C. [19 ]
Schantz, S. [20 ]
Yu, G-P [21 ]
Boffetta, P. [22 ,23 ]
Chuang, S-C [24 ]
Lee, Y-C A. [25 ]
La Vecchia, C. [1 ]
Decarli, A. [1 ]
机构
[1] Univ Milan, Lab Stat Med Biometria Epidemiol GA Maccacaro, Dipartimento Sci Clin & Comunita, I-20133 Milan, Italy
[2] Univ Utah, Sch Med, Div Publ Hlth, Dept Family & Prevent Med, Salt Lake City, UT 84108 USA
[3] Univ Utah, Sch Med, Huntsman Canc Inst, Salt Lake City, UT 84108 USA
[4] Univ Udine, Dept Med & Biol Sci, I-33100 Udine, Italy
[5] Fdn IRCSS Ist Nazl Tumori Milano, SC Stat Med Biometria & Bioinformat, I-20133 Milan, Italy
[6] IRCCS, CRO Aviano Natl Canc Inst, Epidemiol & Biostat Unit, I-33081 Aviano, PN, Italy
[7] Kyushu Univ, Fac Med Sci, Dept Prevent Med, Higashi Ku, Fukuoka 8128582, Japan
[8] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA
[9] Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
[10] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA
[11] Roswell Pk Canc Inst, Buffalo, NY 14263 USA
[12] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA
[13] Univ Michigan, Dept Epidemiol, Sch Publ Hlth, Ann Arbor, MI USA
[14] Univ Michigan, Dept Environm Hlth Sci, Sch Publ Hlth, Ann Arbor, MI USA
[15] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI USA
[16] Lausanne Univ Hosp CHUV, Inst Social & Prevent Med IUMSP, CH-1010 Lausanne, Switzerland
[17] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA
[18] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA
[19] IRCCS Ist Ric Farmacol Mario Negri, Dept Epidemiol, I-20156 Milan, Italy
[20] New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY 10003 USA
[21] Peking Univ, Med Informat Ctr, Beijing, Peoples R China
[22] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA
[23] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA
[24] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Miaoli County, Taiwan
[25] Univ Utah, Sch Med, Dept Family & Prevent Med, Divis Publ Hlth, Salt Lake City, UT 84108 USA
基金
美国国家卫生研究院;
关键词
head and neck cancer; INHANCE; laryngeal cancer; oral and pharyngeal cancer; vitamin E; UPPER AERODIGESTIVE TRACT; SQUAMOUS-CELL CARCINOMA; ANTIOXIDANT VITAMINS; DIETARY PATTERNS; ORAL-CANCER; SERUM MICRONUTRIENTS; PHARYNGEAL CANCER; ALPHA-TOCOPHEROL; RANDOMIZED-TRIAL; SUPPLEMENT USE;
D O I
10.1038/bjc.2015.149
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Evidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited. Methods: We used individual-level pooled data from 10 case-control studies (5959 cases and 12 248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of nonalcohol energy-adjusted vitamin E intake. Results: Intake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile category = 0.59, 95% CI: 0.49-0.71; P for trend <0.001) and to laryngeal cancer (OR = 0.67, 95% CI: 0.54-0.83, P for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral/pharyngeal cancer. Inverse associations were generally observed for the anatomical subsites of oral and pharyngeal cancer and within covariate strata for both sites. Conclusion: Our findings suggest that greater vitamin E intake from foods may lower HNC risk, although we were not able to explain the heterogeneity observed across studies or rule out certain sources of bias.
引用
收藏
页码:182 / 192
页数:11
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