Progesterone receptor polymorphisms and clinical response to 17-alpha-hydroxyprogesterone caproate

被引：58

作者：

Manuck, Tracy A. ^{[2
,4
]}

Lai, Yinglei ^{[2
,3
]}

Meis, Paul J. ^{[2
,5
]}

Dombrowski, Mitchell P. ^{[2
,6
]}

Sibai, Baha ^{[2
,7
]}

Spong, Catherine Y. ^{[1
,2
]}

Rouse, Dwight J. ^{[2
,8
]}

Durnwald, Celeste P. ^{[2
,9
]}

Caritis, Steve N. ^{[2
,10
]}

Wapner, Ronald J. ^{[2
,11
]}

Mercer, Brian M. ^{[2
,12
]}

Ramin, Susan M. ^{[2
,13
]}

机构：

[1] NICHHD, Bethesda, MD 20892 USA

[2] Eunice Kennedy Shriver NICHD Maternal Fetal Med U, Bethesda, MD USA

[3] George Washington Univ, Ctr Biostat, Washington, DC USA

[4] Univ Utah, Dept Obstet & Gynecol, Salt Lake City, UT USA

[5] Wake Forest Univ Hlth Sci, Dept Obstet & Gynecol, Winston Salem, NC USA

[6] Wayne State Univ, Dept Obstet & Gynecol, Detroit, MI USA

[7] Univ Tennessee, Dept Obstet & Gynecol, Memphis, TN 38103 USA

[8] Brown Univ, Sch Med, Dept Obstet & Gynecol, Providence, RI 02912 USA

[9] Ohio State Univ, Dept Obstet & Gynecol, Columbus, OH 43210 USA

[10] Univ Pittsburgh, Dept Obstet & Gynecol, Pittsburgh, PA USA

[11] Thomas Jefferson Univ, Dept Obstet & Gynecol, Philadelphia, PA 19107 USA

[12] Case Western Reserve Univ, Dept Obstet & Gynecol, Cleveland, OH 44106 USA

[13] Univ Texas Houston, Dept Obstet & Gynecol, Houston, TX USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2011年 / 205卷 / 02期

关键词：

genetic polymorphisms; progesterone receptor; recurrent preterm birth; 17-alpha hydroxyprogesterone caproate; PRETERM BIRTH; GENE POLYMORPHISMS; INCREASED RISK; WOMEN; DELIVERY; PREVENTION; WHITE; ASSOCIATION; EXPRESSION; FETAL;

D O I：

10.1016/j.ajog.2011.03.048

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Seventeen-alpha-hydroxyprogesterone caproate (17-OHPC) reduces recurrent preterm birth (PTB). We hypothesized that single nucleotide polymorphisms in the human progesterone receptor (PGR) affect response to 17-OHPC in the prevention of recurrent PTB. STUDY DESIGN: We conducted secondary analysis of a study of 17-OHPC vs placebo for recurrent PTB prevention. Twenty PGR gene single nucleotide polymorphisms were studied. Multivariable logistic regression assessed for an interaction between PGR genotype and treatment status in modulating the risk of recurrent PTB. RESULTS: A total of 380 women were included; 253 (66.6%) received 17-OHPC and 127 (33.4%) received placebo. In all, 61.1% of women were African American. Multivariable logistic regression demonstrated significant treatment-genotype interactions (either a beneficial or harmful treatment response) for African Americans delivering <37 weeks' gestation for rs471767 and rs578029, and for Hispanics/Caucasians delivering <37 weeks' gestation for rs500760 and <32 weeks' gestation for rs578029, rs503362, and rs666553. CONCLUSION: The clinical efficacy and safety of 17-OHPC for recurrent PTB prevention may be altered by PGR gene polymorphisms.

引用

页码：135.e1 / 135.e9

页数：9

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