A stereoselective approach to the synthesis of γ-silylated amino acids.

被引：14

作者：

Reginato, G ^{[1
]}

Mordini, A ^{[1
]}

Valacchi, M ^{[1
]}

机构：

[1] CNR, Ctr Studio Chim & Struttura Composti Eterocicl &, I-50121 Florence, Italy

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 51期

关键词：

addition reaction; amino acids and derivatives; copper and compounds; regiocontrol; stereocontrol; silicon and compounds;

D O I：

10.1016/S0040-4039(98)02120-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of enantiomerically enriched silicon containing amino acids is described. Silylcupration of 2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine, easily derived from serine aldehyde, afforded regio- and stereoselectively gamma-silylated ethenyloxazolidines of (E)-geometry as useful precursors of saturated and unsaturated gamma-silylated amino acids. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9545 / 9548

页数：4

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