A stereoselective approach to the synthesis of γ-silylated amino acids.

被引：14
|
作者：
Reginato, G [1 ]
Mordini, A [1 ]
Valacchi, M [1 ]
机构：
[1] CNR, Ctr Studio Chim & Struttura Composti Eterocicl &, I-50121 Florence, Italy
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 51期
关键词：
addition reaction; amino acids and derivatives; copper and compounds; regiocontrol; stereocontrol; silicon and compounds;
D O I：
10.1016/S0040-4039(98)02120-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of enantiomerically enriched silicon containing amino acids is described. Silylcupration of 2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine, easily derived from serine aldehyde, afforded regio- and stereoselectively gamma-silylated ethenyloxazolidines of (E)-geometry as useful precursors of saturated and unsaturated gamma-silylated amino acids. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：9545 / 9548
页数：4
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