An improved synthesis of the "miracle nutrient" coenzyme Q10

被引：63
|
作者：
Lipshutz, BH [1 ]
Lower, A
Berl, V
Schein, K
Wetterich, F
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
[2] BASF AG, GV B9, D-67056 Ludwigshafen, Germany
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 19期
关键词：
D O I：
10.1021/ol051329y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new route to the key coupling partner, chloromethylated CoQ(0) (1), allows for direct formation of CoQ(10) (3) via nickel-catalyzed cross-coupling with the side chain in the form of an in situ-derived vinyl alane (2).
引用
收藏
页码：4095 / 4097
页数：3
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