An improved synthesis of the "miracle nutrient" coenzyme Q10

被引：63

作者：

Lipshutz, BH ^{[1
]}

Lower, A

Berl, V

Schein, K

Wetterich, F

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[2] BASF AG, GV B9, D-67056 Ludwigshafen, Germany

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 19期

关键词：

D O I：

10.1021/ol051329y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route to the key coupling partner, chloromethylated CoQ(0) (1), allows for direct formation of CoQ(10) (3) via nickel-catalyzed cross-coupling with the side chain in the form of an in situ-derived vinyl alane (2).

引用

页码：4095 / 4097

页数：3

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