Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives

被引：28

作者：

Aytemir, Mutlu Dilsiz ^{[1
]}

Ozcelik, Berrin ^{[2
]}

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Gazi Univ, Dept Pharmaceut Microbiol, Fac Pharm, TR-06330 Ankara, Turkey

来源：

MEDICINAL CHEMISTRY RESEARCH | 2011年 / 20卷 / 04期

关键词：

Chlorokojic acid; Kojic acid; Mannich bases; Antimicrobial; Antiviral; KOJIC ACID; ANTICONVULSANT;

D O I：

10.1007/s00044-010-9338-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one derivatives were synthesized and tested for their antibacterial, antifungal and antiviral in vitro properties. In the view of activity results, compounds 8-11 (MIC: 8 mu g/ml) were more remarkably active against Staphylococcus aureus and Enterococcus faecalis. Compounds 1-7 were highly active against Candida albicans and C. parapsilosis with MIC value of 8 mu g/ml. Compound 9 bearing 3-chlorophenyl moiety was determined to be the most active compound against RNA virus PI-3.

引用

页码：443 / 452

页数：10