Enantioselective Dearomative Cyclization of Homotryptamines with Allenamides into Indolo[2,3-b]quinolines

被引：17

作者：

Biswas, Soumen ^{[1
,2
]}

Kim, Hanbyul ^{[1
,2
]}

Cao, Kiet Le Anh ^{[1
,2
]}

Shin, Seunghoon ^{[1
,2
]}

机构：

[1] Hanyang Univ, Dept Chem, Res Inst Nat Sci, 222 Wangsimni Ro, Seoul 04763, South Korea

[2] Hanyang Univ, Ctr New Direct Organ Synth CNOS, 222 Wangsimni Ro, Seoul 04763, South Korea

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2020年 / 362卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

dearomative cyclization; homotryptamine; indolo[2; 3-b]quinolines; chiral Bronsted acid catalysis; CATALYTIC ASYMMETRIC DEAROMATIZATION; 4+2 CYCLOADDITION; INDOLES; PYRROLOINDOLINES; CONSTRUCTION; STRATEGY; FACILE;

D O I：

10.1002/adsc.202000083

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We have developed a catalytic asymmetric dearomative cyclization of homotryptamine derivatives, furnishing enantioenriched indolo[2,3-b]quinoline scaffolds. The activation of allenamides in the presence of chiral phosphoric acids triggered the dearomative cyclization in up to 99% ee.

引用

收藏

页码：1841 / 1845

页数：5

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