Three-dimensional bioactive glass implants fabricated by rapid prototyping based on CO2 laser cladding

被引：45

作者：

Comesana, R. ^{[1
]}

Lusquinos, F. ^{[1
]}

del Val, J. ^{[1
]}

Lopez-Alvarez, M. ^{[1
]}

Quintero, F. ^{[1
]}

Riveiro, A. ^{[1
]}

Boutinguiza, M. ^{[1
]}

de Carlos, A. ^{[2
]}

Jones, J. R. ^{[3
]}

Hill, R. G. ^{[4
]}

Pou, J. ^{[1
]}

机构：

[1] Univ Vigo, Dept Appl Phys, ETSII, E-36310 Vigo, Spain

[2] Univ Vigo, Fac Biol, Biochem Genet & Immunol Dept, E-36310 Vigo, Spain

[3] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London SW7 2AZ, England

[4] Barts & London Unit Dent & Phys Sci, London E1 4NS, England

来源：

ACTA BIOMATERIALIA | 2011年 / 7卷 / 09期

基金：

英国工程与自然科学研究理事会;

关键词：

Bioactive glass; Rapid prototyping; Laser cladding; Cranioplasty; Tissue engineering; CALCIUM-PHOSPHATE COATINGS; ORBITAL FLOOR FRACTURES; IN-VITRO; TAPE CAST; COMPOSITIONAL DEPENDENCE; BONE; CRYSTALLIZATION; SCAFFOLDS; 45S5; RECONSTRUCTION;

D O I：

10.1016/j.actbio.2011.05.023

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Three-dimensional bioactive glass implants were produced by rapid prototyping based on laser cladding without using moulds. CO2 laser radiation was employed to melt 45S5 and S520 bioactive glass particles and to deposit the material layer by layer following a desired geometry. Controlled thermal input and cooling rate by fine tuning of the processing parameters allowed the production of crack-free fully dense implants. Microstructural characterization revealed chemical composition stability, but crystallization during processing was extensive when 45S5 bioactive glass was used. Improved results were obtained using the S520 bioactive glass, which showed limited surface crystallization due to an expanded sintering window (the difference between the glass transition temperature and crystallization onset temperature). Ion release from the S520 implants in Iris buffer was similar to that of amorphous 45S5 bioactive glass prepared by casting in graphite moulds. Laser processed S520 scaffolds were not cytotoxic in vitro when osteoblast-like MC3T3-E1 cells were cultured with the dissolution products of the glasses; and the MC3T3-E1 cells attached and spread well when cultured on the surface of the materials. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：3476 / 3487

页数：12

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