Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger

被引：12
|
作者：
Tucker, JE
Winkfein, RJ
Murthy, SK
Friedman, JS
Walter, MA
Demetrick, DJ
Schnetkamp, PPM
机构：
[1] Univ Calgary, Fac Med, Dept Biochem & Mol Biol, Calgary, AB, Canada
[2] Univ Calgary, Fac Med, MRC, Grp Ion Channels Transporters, Calgary, AB, Canada
[3] Univ Calgary, Fac Med, Dept Pathol, Calgary, AB, Canada
[4] Univ Alberta, Dept Med Genet, Heritage Med Res Ctr, Edmonton, AB T6G 2S2, Canada
[5] Univ Alberta, Dept Ophthalmol, Heritage Med Res Ctr, Edmonton, AB T6G 2S2, Canada
来源：
HUMAN GENETICS | 1998年 / 103卷 / 04期
基金：
英国医学研究理事会;
关键词：
Calcium; Retina; Untranslated Region; Chromosome 15q22; Chromosomal Localization;
D O I：
10.1007/s004390050842
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The retinal rod Na-Ca+K exchanger is a unique calcium extrusion protein found only in the outer segments of retinal rod photoreceptors. Rod Na-Ca+K exchanger cDNA (NCKX1) has been cloned from bovine and human retinas. Here, we have used fluorescent in situ hybridization and radiation hybrid mapping to localize the human NCKX1 gene to chromosome 15q22. We have determined the genomic organization of human rod NCKX1 and found one intron in the 5' untranslated region and eight introns within the coding region.
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收藏
页码：411 / 414
页数：4
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