The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension

被引：92

作者：

Quadery, Syed Rehan ^{[1
,2
]}

Swift, Andrew J. ^{[3
,4
]}

Billings, Catherine G. ^{[1
,2
]}

Thompson, Alfred A. R. ^{[1
,2
,3
]}

Elliot, Charles A. ^{[1
,2
]}

Hurdman, Judith ^{[1
,2
]}

Charalampopoulos, Athanasios ^{[1
]}

Sabroe, Ian ^{[1
,2
,3
]}

Armstrong, Iain J. ^{[1
]}

Hamilton, Neil ^{[1
]}

Sephton, Paul ^{[1
]}

Garrad, Sian ^{[1
]}

Pepke-Zaba, Joanna ^{[5
]}

Jenkins, David P. ^{[5
]}

Screaton, Nicholas ^{[5
]}

Rothman, Alexander M. ^{[3
]}

Lawrie, Allan ^{[3
]}

Cleveland, Trevor ^{[6
]}

Thomas, Steven ^{[6
]}

Rajaram, Smitha ^{[6
]}

Hill, Catherine ^{[6
]}

Davies, Christine ^{[6
]}

Johns, Christopher S. ^{[6
]}

Wild, Jim M. ^{[3
,4
]}

Condliffe, Robin ^{[1
,2
]}

Kiely, David G. ^{[1
,2
,3
,4
]}

机构：

[1] Sheffield Teaching Hosp NHS Fdn Trust, Royal Hallamshire Hosp, Sheffield Pulm Vasc Dis Unit, Glossop Rd, Sheffield S10 2JF, S Yorkshire, England

[2] Sheffield Teaching Hosp NHS Fdn Trust, Acad Directorate Resp Med, Sheffield, S Yorkshire, England

[3] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England

[4] Univ Sheffield, Insigneo Inst Silico Med, Sheffield, S Yorkshire, England

[5] Papworth Hosp NHS Fdn Trust, Pulm Vasc Dis Unit, Cambridge, England

[6] Sheffield Teaching Hosp NHS Fdn Trust, Dept Radiol, Sheffield, S Yorkshire, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2018年 / 52卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

LONG-TERM OUTCOMES; TREATED PATIENTS; ENDARTERECTOMY; MANAGEMENT; DIAGNOSIS; ANGIOPLASTY; GUIDELINES; EXPERIENCE; PREDICTORS; SILDENAFIL;

D O I：

10.1183/13993003.00589-2018

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Pulmonary endarterectomy (PEA) is the gold standard treatment for operable chronic thromboembolic pulmonary hypertension (CTEPH). However, a proportion of patients with operable disease decline surgery. There are currently no published data on this patient group. The aim of this study was to identify outcomes and prognostic factors in a large cohort of consecutive patients with CTEPH. Data were collected for consecutive, treatment-naive CTEPH patients at the Pulmonary Vascular Disease Unit of the Royal Hallamshire Hospital (Sheffield, UK) between 2001 and 2014. Of 550 CTEPH patients (mean +/- SD age 63 +/- 15 years, follow-up 4 +/- 3 years), 49% underwent surgery, 32% had technically operable disease and did not undergo surgery (including patient choice n=72 and unfit for surgery n=63), and 19% had inoperable disease due to disease distribution. The 5-year survival was superior in patients undergoing PEA (83%) versus technically operable disease who did not undergo surgery (53%) and inoperable due to disease distribution (59%) (p<0.001). Survival was superior in patients following PEA compared with those offered but declining surgery (55%) (p<0.001). In patients offered PEA, independent prognostic factors included mixed venous oxygen saturation, gas transfer and patient decision to proceed to surgery. Outcomes in CTEPH following PEA are excellent and superior to patients declining surgery, and strongly favour consideration of a surgical intervention in eligible patients.

引用

页数：12

共 40 条

[1] Predictors of outcome in chronic thromboembolic pulmonary hypertension [J].

Bonderman, Diana ;

Skoro-Sajer, Nika ;

Jakowitsch, Johannes ;

Adlbrecht, Christopher ;

Dunkler, Daniela ;

Taghavi, Sharokh ;

Klepetko, Walter ;

Kneussl, Meinhard ;

Lang, Irene M. .

CIRCULATION, 2007, 115 (16) :2153-2158

[2] Is Distal Chronic Thromboembolic Pulmonary Hypertension Treatable with PAH Targeted Drugs? [J].

Cannon, J. E. ;

Pepke-Zaba, J. .

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 34 (05) :620-626

[3] Dynamic Risk Stratification of Patient Long-Term Outcome After Pulmonary Endarterectomy Results From the United Kingdom National Cohort [J].

Cannon, John E. ;

Su, Li ;

Kiely, David G. ;

Page, Kathleen ;

Toshner, Mark ;

Swietlik, Emilia ;

Treacy, Carmen ;

Ponnaberanam, Anie ;

Condliffe, Robin ;

Sheares, Karen ;

Taboada, Dolores ;

Dunning, John ;

Tsui, Steven ;

Ng, Choo ;

Gopalan, Deepa ;

Screaton, Nicholas ;

Elliot, Charlie ;

Gibbs, Simon ;

Howard, Luke ;

Corris, Paul ;

Lordan, James ;

Johnson, Martin ;

Peacock, Andrew ;

MacKenzie-Ross, Robert ;

Schreiber, Benji ;

Coghlan, Gerry ;

Dimopoulos, Kostas ;

Wort, Stephen J. ;

Gaine, Sean ;

Moledina, Shahin ;

Jenkins, David P. ;

Pepke-Zaba, Joanna .

CIRCULATION, 2016, 133 (18) :1761-+

[4] Prognostic and aetiological factors in chronic thromboembolic pulmonary hypertension [J].

Condliffe, R. ;

Kiely, D. G. ;

Gibbs, J. S. R. ;

Corris, P. A. ;

Peacock, A. J. ;

Jenkins, D. P. ;

Goldsmith, K. ;

Coghlan, J. G. ;

Pepke-Zaba, J. .

EUROPEAN RESPIRATORY JOURNAL, 2009, 33 (02) :332-337

[5] Improved outcomes in medically and surgically treated chronic thromboembolic pulmonary hypertension [J].

Condliffe, Robin ;

Kiely, David G. ;

Gibbs, J. Simon R. ;

Corris, Paul A. ;

Peacock, Andrew J. ;

Jenkins, David P. ;

Hodgkins, Denise ;

Goldsmith, Kim ;

Hughes, Rodney J. ;

Sheares, Karen ;

Tsui, Steven S. L. ;

Armstrong, Iain J. ;

Torpy, Chantal ;

Crackett, Rachel ;

Carlin, Christopher M. ;

Das, Clare ;

Coghlan, J. Gerry ;

Pepke-Zaba, Joanna .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (10) :1122-1127

[6] Long-term outcome after pulmonary endarterectomy [J].

Corsico, Angelo G. ;

D'Armini, Andrea M. ;

Cerveri, Isa ;

Klersy, Catherine ;

Ansaldo, Elena ;

Niniano, Rosanna ;

Gatto, Elena ;

Monterosso, Cristian ;

Morsolini, Marco ;

Nicolardi, Salvatore ;

Tramontin, Corrado ;

Pozzi, Ernesto ;

Vigano, Mario .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 178 (04) :419-424

[7] Pulmonary endarterectomy for distal chronic thromboembolic pulmonary hypertension [J].

D'Armini, Andrea M. ;

Morsolini, Marco ;

Mattiucci, Gabriella ;

Grazioli, Valentina ;

Pin, Maurizio ;

Valentini, Adele ;

Silvaggio, Giuseppe ;

Klersy, Catherine ;

Dore, Roberto .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2014, 148 (03) :1005-1011

[8] Long-Term Outcome of Patients With Chronic Thromboembolic Pulmonary Hypertension Results From an International Prospective Registry [J].

Delcroix, Marion ;

Lang, Irene ;

Pepke-Zaba, Joanna ;

Jansa, Pavel ;

D'Armini, Andrea M. ;

Snijder, Repke ;

Bresser, Paul ;

Torbicki, Adam ;

Mellemkjaer, Soren ;

Lewczuk, Jerzy ;

Simkova, Iveta ;

Barbera, Joan A. ;

de Perrot, Marc ;

Hoeper, Marius M. ;

Gaine, Sean ;

Speich, Rudolf ;

Gomez-Sanchez, Miguel A. ;

Kovacs, Gabor ;

Jais, Xavier ;

Ambroz, David ;

Treacy, Carmen ;

Morsolini, Marco ;

Jenkins, David ;

Lindner, Jaroslav ;

Dartevelle, Philippe ;

Mayer, Eckhard ;

Simonneau, Gerald .

CIRCULATION, 2016, 133 (09) :859-871

[9] Management and outcomes in chronic thromboembolic pulmonary hypertension: From expert centers to a nationwide perspective [J].

Escribano-Subias, P. ;

del Pozo, R. ;

Roman-Broto, A. ;

Morera, J. A. Domingo ;

Lara-Padron, A. ;

Hernandez, T. Elias ;

Molina-Ferragut, L. ;

Blanco, I. ;

Cortina, J. ;

Barbera, J. A. .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2016, 203 :938-944

[10]

Feinstein JA, 2001, CIRCULATION, V103, P10

← 1 2 3 4 →