Regioselective palladium-catalyzed arylation of 2-furaldehyde

被引：148

作者：

McClure, MS ^{[1
]}

Glover, B ^{[1
]}

McSorley, E ^{[1
]}

Millar, A ^{[1
]}

Osterhout, MH ^{[1
]}

Roschangar, F ^{[1
]}

机构：

[1] GlaxoSmithKline, Chem Dev, Res Triangle Pk, NC 27709 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 11期

关键词：

D O I：

10.1021/ol0158866

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An efficient regioselective method for the direct arylation of 2-furaldehyde to provide a range of,pi -diverse 5-aryl-2-formylfuran derivatives is described. The method employs functionalized aryl halides and a catalytic amount of palladium(ll) chloride under relatively mild conditions.

引用

页码：1677 / 1680

页数：4

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