Mechanism of the protective action of glyprolines during stress and inflammation

被引：0

作者：

Umarova, B. A. ^{[1
]}

Kopylova, G. N. ^{[1
]}

Lelekova, T. V. ^{[1
]}

Smirnova, E. A. ^{[1
]}

Samonina, G. E. ^{[1
]}

Bakaeva, Z. V. ^{[1
]}

Goncharova, E. L. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Biol, Dept Human & Anim Physiol, Moscow 119991, Russia

来源：

NEUROCHEMICAL JOURNAL | 2008年 / 2卷 / 1-2期

关键词：

regulatory peptides; stress; inflammation; mast cells;

D O I：

10.1134/S1819712408010194

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stress and the induction of inflammation result in disorders in the microcirculation bed of rat mesentery as well as inhibition of the reaction of lymphatic vessels in response to application of noradrenaline (NA). These disorders are associated with increased secretion by mast cells and point to the important role of these cells in the development of pathological changes in functions of lymphatic vessels. Peptides of the glyproline fan-Lily can prevent disorders of the functional state of the microcirculation bed of the mesentery during both inflammation and stress reactions. This property is associated, to some extent, with their stabilizing effect on mast cells. Inhibition of mast cell activity by glyprolines may be one of the mechanisms of their action in a wide spectrum of pathological processes.

引用

页码：102 / 106

页数：5

共 15 条

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