Palladium-catalyzed one-pot synthesis of 2-alkyl-2-arylcyanoacetates

被引：14
|
作者：
Wang, Xiang [1 ]
Guram, Anil [1 ]
Bunel, Emilio [1 ]
Cao, Guo-Qiang [1 ]
Allen, Jennifer R. [1 ]
Faul, Margaret M. [1 ]
机构：
[1] Amgen Inc, Chem Proc R&D, Thousand Oaks, CA 91320 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 04期
关键词：
D O I：
10.1021/jo7024338
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A one-pot procedure for the synthesis of 2-alkyl-2-arylcyanoacetates based on a Pd(OAc)(2)/DPPF (DPPF = 1,1'-diphenylphosphino ferreocene)-catalyzed enolate arylation followed by in situ alkylation has been developed. This procedure tolerates a diverse range of aryl and heteroaryl bromides, and provides a rapid entry to a variety of 2-alkyl-2-arylcyanoacetates in good to excellent yield.
引用
收藏
页码：1643 / 1645
页数：3
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