Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine

被引：10
|
作者：
Finotti, Michele [1 ]
Vitale, Alessandro [1 ]
Gringeri, Enrico [1 ]
D'Amico, Francesco Enrico [1 ]
Boetto, Riccardo [1 ]
Bertacco, Alessandra [1 ]
Lonardi, Sara [2 ]
Bergamo, Francesca [2 ]
Feltracco, Paolo [3 ]
Cillo, Umberto [1 ]
机构：
[1] Univ Padua, Transplantat & Hepatobiliary Surg, Padua, Italy
[2] Veneto Inst Oncol IOV Ist Ricovero & Cura Caratte, Unit Oncol 1, Dept Oncol, Padua, Italy
[3] Azienda Osped Padova, Anesthesia & Intens Care Unit, Padua, Italy
来源：
FRONTIERS IN SURGERY | 2021年 / 8卷
关键词：
liver resection; transplant benefit; prioritization; immunosopressive therapy; recurrence; TUMOR BURDEN SCORE; COLORECTAL-CANCER; HEPATOCELLULAR-CARCINOMA; HEPATIC RESECTION; CLINICAL SCORE; RECURRENCE; SURVIVAL; CHEMOTHERAPY; FOLFOX4; NUMBER;
D O I：
10.3389/fsurg.2021.693387
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The development of liver metastases in colon rectal cancer has a strong impact on the overall survival (OS) of the patient, with a 5-year survival rate of 5% with palliative treatment. Surgical resection combined with pharmacological treatment can achieve a 5-year OS rate of 31-58%. However, in only 20% of patients with colon rectal liver metastases (CRLMs), liver resection is feasible. In highly selected patients, recent trials and studies proved that liver transplantation (LT) for non-resectable CRLM is a surgical option with an excellent long-term OS. The paper aims to review the indications and outcome of LT for CRLMs, with a special focus on immunosuppressive therapy and the management of local and extrahepatic recurrence after LT.
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页数：14
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