NOAH: NMR Supersequences for Small Molecule Analysis and Structure Elucidation

被引：61

作者：

Kupce, Eriks ^{[2
]}

Claridge, Tim D. W. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Mansfield Rd, Oxford OX1 3TA, England

[2] Bruker UK Ltd, Banner Lane, Coventry CV4 9GH, W Midlands, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 39期

关键词：

COSY; HSQC; NMR techniques; NOAH; structure elucidation; SPECTROSCOPY; ACQUISITION; SPECTRA; STATE; PROTEINS; HMBC;

D O I：

10.1002/anie.201705506

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nested NMR experiments combining up to five conventional NMR pulse sequences into one supersequence are introduced. The core 2D NMR techniques routinely employed in small molecule NMR spectroscopy, such as HSQC, HMQC, HMBC, COSY, NOESY, TOCSY, and similar, can be recorded in a single measurement. In this way the data collection time may be dramatically reduced and sample throughput increased for basic NMR applications, such as structure elucidation and verification in synthetic, medicinal, and natural product chemistry.

引用

页码：11779 / 11783

页数：5

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