Preparation and in Vitro Evaluation of Carboxymethyl Konjac Glucomannan Coated 5-Aminosalicylic Acid Tablets for Colonic Delivery

被引：6

作者：

Yan, Long Xiao ^{[1
]}

Gang, Luo Xue ^{[1
]}

Wu, Zou Neng ^{[1
]}

Hong, Ma Yong ^{[1
]}

机构：

[1] SW Univ Sci & Technol, Sch Life Sci & Engn, Mianyang 621000, Peoples R China

来源：

NEW MATERIALS AND ADVANCED MATERIALS, PTS 1 AND 2 | 2011年 / 152-153卷

关键词：

Carboxymethyl konjac glucomannan; Mannanase; 5-aminosalicylic acid; colon-specific delivery; in vitro; DRUG-DELIVERY;

D O I：

10.4028/www.scientific.net/AMR.152-153.1712

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Konjac Glucomannan(KGM) was denatured by Carboxylmethylation to prepare Carboxymethyl konjac glucomannan(CMKGM) as coating material of 5-aminosalicylic acid(5-ASA) tablets. The 5-ASA release properties of the tablets were measured in vitro in the gastrointestinal tract simulation environment and in buffer solutions with beta-mannase of pH 6.8 at 37 +/- 0.5 degrees. The properties of the CMKGM were analyzed by FTIR spectra, viscosity measurement and swelling measurement. The integrality of the 5-ASA was investigated by ultraviolet spectrometry. The viscosity and swelling showed that CMKGM has lower swelling and lower viscosity compared to KGM. 5-ASA was released least in stimulating gastric environment and in pH 6.8 phosphate buffers,while the preparation was fast released in pH 6.8 phosphate buffers with beta-mannase. The preparation was released 14% after 4 hours in pH 6.8 phosphate buffers, at the same time the preparation in pH 6.8 phosphate buffers with 0.2u ml(-1) beta-mannase was released 97% in 12 hours. The results suggested that CMKGM may be a useful carrier of 5-ASA for colon-specific delivery. It has a potential use for advanced controlled release.

引用

页码：1712 / 1715

页数：4