Green polymer chemistry: Precision synthesis of novel multifunctional poly(ethylene glycol)s using enzymatic catalysis

被引：37
作者：
Puskas, Judit E. [1 ]
Seo, Kwang Su [1 ]
Sen, Mustafa Y. [1 ]
机构：
[1] Univ Akron, Dept Polymer Sci, Akron, OH 44325 USA
来源：
EUROPEAN POLYMER JOURNAL | 2011年 / 47卷 / 04期
基金：
美国国家科学基金会;
关键词：
Green chemistry; Enzymes; Poly(ethylene glycol); Functionalization; Dendrimer; IRREVERSIBLE ACYL TRANSFER; MICHAEL ADDITION; BIOMEDICAL APPLICATIONS; STAR POLYISOPRENES; ORGANIC-SOLVENTS; LIPASE CATALYSIS; TRANSFER AGENTS; DRUG-DELIVERY; DENDRIMERS; TRANSESTERIFICATION;
D O I：
10.1016/j.eurpolymj.2010.10.015
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
This paper gives an overview about enzyme catalysis, and reports the precision synthesis of multifunctional poly(ethylene glycol)s using this green chemistry approach. Specifically, vinyl acrylate was transesterified with tetraethylene glycol (TEG) and a PEG with DPn = 23, and then (HO)(2)-TEG-(OH)(2) and (HO)(2)-PEG-(OH)(2) were synthesized by the Michael addition of diethanolamine to the acrylate double bonds. These structures will serve as the core of novel dendrimers designed for drug delivery applications. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：524 / 534
页数：11
相关论文
共 71 条
  • [1] Banerjee S, 1998, ACS SYM SER, V684, P125
  • [2] Enzymatic surface modification of acrylonitrile fibers
    Battistel, E
    Morra, M
    Marinetti, M
    [J]. APPLIED SURFACE SCIENCE, 2001, 177 (1-2) : 32 - 41
  • [3] ANHYDRIDES AS ACYLATING AGENTS IN LIPASE-CATALYZED STEREOSELECTIVE ESTERIFICATION OF RACEMIC ALCOHOLS
    BIANCHI, D
    CESTI, P
    BATTISTEL, E
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (23) : 5531 - 5534
  • [4] Proteases in organic synthesis
    Bordusa, F
    [J]. CHEMICAL REVIEWS, 2002, 102 (12) : 4817 - 4867
  • [5] About dendrimers: Structure, physical properties, and applications
    Bosman, AW
    Janssen, HM
    Meijer, EW
    [J]. CHEMICAL REVIEWS, 1999, 99 (07) : 1665 - 1688
  • [6] Hydrolase-catalyzed Michael addition of imidazoles to acrylic monomers in organic medium
    Cai, Y
    Wu, Q
    Xiao, YM
    Lv, DS
    Lin, XF
    [J]. JOURNAL OF BIOTECHNOLOGY, 2006, 121 (03) : 330 - 337
  • [7] Alkaline protease from Bacillus subtilis catalyzed Michael addition of pyrimidine derivatives to α,β-ethylenic compounds in organic media
    Cai, Y
    Sun, XF
    Wang, N
    Lin, XF
    [J]. SYNTHESIS-STUTTGART, 2004, (05): : 671 - 674
  • [8] RATIONAL CONTROL OF POLYMER MOLECULAR-WEIGHT AND DISPERSITY DURING ENZYME-CATALYZED POLYESTER SYNTHESIS IN SUPERCRITICAL FLUIDS
    CHAUDHARY, AK
    BECKMAN, EJ
    RUSSELL, AJ
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (13) : 3728 - 3733
  • [9] Cheng H. N., 2001, P567, DOI 10.1201/9780585407500.ch15
  • [10] CRABTREE RH, 2009, HDB GREEN CATALYSIS, V3, P174
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