Synthesis of potentially bioactive PABA-related N-(aminoalkyl)lactamic amino acids and esters via selective SNAr reactions

被引：12

作者：

Goncalves, Renato S. ^{[1
,2
]}

Abdelnur, Patricia V. ^{[3
]}

Santos, Vanessa G. ^{[3
]}

Simas, Rosineide C. ^{[3
]}

Eberlin, Marcos N. ^{[3
]}

Magalhaes, Alvicler ^{[4
]}

Perez Gonzalez, Eduardo R. ^{[1
]}

机构：

[1] Univ Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, Lab Quim Organ Fina, BR-19060900 Presidente Prudente, SP, Brazil

[2] Univ Estadual Paulista, Programa Posgrad Ciencia & Tecnol Mat POSMAT, Sao Paulo, Brazil

[3] Univ Estadual Campinas, UNICAMP, Inst Quim, Lab ThoMSon Espectrometria Massas, Campinas, SP, Brazil

[4] Univ Estadual Campinas, UNICAMP, Inst Quim, Dept Quim Inorgan, Campinas, SP, Brazil

来源：

AMINO ACIDS | 2011年 / 40卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

PABA derivatives; Lactams; Potential bio-activity; SNAr reaction; DERIVATIVES; INHIBITORS;

D O I：

10.1007/s00726-010-0634-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by SNAr reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition-elimination SNAr mechanism was confirmed by NMR and MS measurements.

引用

页码：197 / 204

页数：8

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