Emotion Dysregulation and Inflammation in African-American Women with Type 2 Diabetes

被引：22

作者：

Powers, Abigail ^{[1
]}

Michopoulos, Vasiliki ^{[1
]}

Conneely, Karen ^{[2
]}

Gluck, Rachel ^{[1
]}

Dixon, Hayley ^{[1
]}

Wilson, Joseph ^{[1
]}

Jovanovic, Tanja ^{[1
]}

Pace, Thaddeus W. W. ^{[3
,4
]}

Umpierrez, Guillermo E. ^{[5
]}

Ressler, Kerry J. ^{[1
,6
]}

Bradley, Bekh ^{[1
,7
]}

Gillespie, Charles F. ^{[1
]}

机构：

[1] Emory Univ, Sch ofMedicine, Dept Psychiat & Behav Sci, Jesse Hill Jr Dr, Atlanta, GA 30306 USA

[2] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA USA

[3] Univ Arizona, Coll Nursing, Tucson, AZ 85721 USA

[4] Univ Arizona, Coll Med Psychiat, Tucson, AZ USA

[5] Emory Univ, Sch Med, Dept Med, Div Endocrinol, Atlanta, GA USA

[6] Harvard Univ, Ctr Depress Anxiety & Stress Res, Cambridge, MA 02138 USA

[7] Atlanta VA Med Ctr, Atlanta, GA USA

来源：

NEURAL PLASTICITY | 2016年 / 2016卷

关键词：

C-REACTIVE PROTEIN; POSTTRAUMATIC-STRESS-DISORDER; MAJOR DEPRESSIVE DISORDER; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; SOCIOECONOMIC-STATUS; ASSOCIATION; SYMPTOMS; RISK;

D O I：

10.1155/2016/8926840

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

C-reactive protein (CRP), a marker of systemic inflammation, has been associated with major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). Emotion dysregulation is a transdiagnostic risk factor for many psychological disorders associated with chronic inflammatory state. The objective of this study was to determine whether inflammation is associated with emotion dysregulation in women with type 2 diabetes mellitus (T2DM). We examined associations between trauma exposure, MDD, PTSD, emotion dysregulation, and CRP among 40 African-American women with T2DM recruited from an urban hospital. Emotion dysregulation was measured using the Difficulties in Emotion Regulation Scale. PTSD and MDD were measured with structured clinical interviews. Child abuse and lifetime trauma load were also assessed. Analyses showed that both emotion dysregulation and current MDD were significantly associated with higher levels of CRP (p < 0.01). Current PTSD was not significantly related to CRP. In a regression model, emotion dysregulation was significantly associated with higher CRP (p < 0.001) independent of body mass index, trauma exposure, and MDD diagnosis. These findings suggest that emotion dysregulation may be an important risk factor for chronic inflammation beyond already known risk factors among women with T2DM, though a causal relationship cannot be determined from this study.

引用

页数：10

共 66 条

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