Synthesis and photobiological activity of N-substituted 2-oxo-2H-1-benzopyran-3-(thio)carboxamides.

被引：0
|
作者：
ElAhmad, Y [1 ]
Brion, JD [1 ]
Reynaud, P [1 ]
Averbeck, D [1 ]
Averbeck, S [1 ]
机构：
[1] INST CURIE, SECT RECH, CNRS, UMR 218, F-75231 PARIS 05, FRANCE
来源：
HETEROCYCLES | 1996年 / 43卷 / 10期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Several polyfunctional coumarins and the corresponding quaternary ammoniums, associated with a coplanar structure have been synthesized in order to test the relationships between structure and photobiological activity. In vitro studies on their phototoxic effects in yeasts suggest that five of them are able to intercalate in DNA and to covalently photobind to DNA.
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收藏
页码：2169 / 2177
页数：9
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