Synthesis and evaluation of antibacterial and antibiofilm activities of pyridin-2-yl hexanoate

被引：2
作者：
Kouidhi, Bochra [1 ]
Hagar, Mohamed [2 ,3 ]
Radwan, Nagi R. E. [2 ,4 ]
Chaieb, Kamel [5 ]
机构：
[1] Yanbu el Baher Taibah Univ, Coll Appl Med Sci, Med Lab Dept, Yanbu, Saudi Arabia
[2] Yanbu el Baher Taibah Univ, Chem Dept, Coll Sci, Yanbu, Saudi Arabia
[3] Alexandria Univ, Chem Dept, Fac Sci, Alexandria, Egypt
[4] Suez Univ, Chem Dept, Fac Sci, Suez, Egypt
[5] Monastir Univ, Fac Pharm, Lab Anal Treatment & Valorizat Pollutants Environ, Monastir, Tunisia
来源：
MICROBIAL PATHOGENESIS | 2018年 / 125卷
关键词：
Pyridin-2-yl hexanoate; Antibacterial; XTT assay; Antibiofilm; BIOFILMS; CYTOTOXICITY; DERIVATIVES; INHIBITION; CHEMISTRY; RING;
D O I：
10.1016/j.micpath.2018.09.022
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Synthesized Pyridin-2-yl hexanoate was screened for its antibacterial and antibiofilm activities using the broth microdilution method and XTT assay respectively. The obtained results revealed that synthesized molecule inhibited the growth of pathogenic bacteria (MICs value ranged from 80 to 640 mu g ml(-1)). Moreover, it induced a strong antibiofilm effect against Gram positive cocci (BIC50 was 366, 378 and 412 mu g ml(-1) for Streptococcus mutans ATCC 25175, Streptococcus salivarius ATCC 13419 and Streptococcus oralis ATCC 6249 respectively). Basis on these results, pyridin-2-yl hexanoate may be considered as effective compound with antibacterial and antibiofilm activities.
引用
收藏
页码：205 / 209
页数：5
相关论文
共 50 条
  • [41] Comprehensive evaluation of the antibacterial and antibiofilm activities of NiTi orthodontic wires coated with silver nanoparticles and nanocomposites: an in vitro study
    Abdallah, Omnia M.
    Sedky, Youssef
    Shebl, Heba R.
    BMC ORAL HEALTH, 2024, 24 (01):
  • [42] Synthesis, antimicrobial and antimycobacterial evaluation of [2-(substitutedphenyl)-imidazol-1-yl]-pyridin-3-yl-methanones
    Narasimhan, Balasubramanian
    Sharma, Deepika
    Kumar, Pradeep
    Yogeeswari, Perumal
    Sriram, Dharmarajan
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2011, 26 (05) : 720 - 727
  • [43] Environmentally Friendly Synthesis of Coumarin–Pyrazolo[1,5-a]pyrimidine Hybrids with Potent Antibacterial and Antibiofilm Activities
    T. R. A. Sangma
    L. B. Marpna
    M. Rymbai
    S. Kaping
    V. V. Borah
    J. N. Vishwakarma
    Russian Journal of Bioorganic Chemistry, 2025, 51 (3) : 1306 - 1319
  • [44] An Experimental and Theoretical Insight into I2/Br2 Oxidation of Bis(pyridin-2-yl)Diselane and Ditellane
    Aragoni, M. Carla
    Podda, Enrico
    Chaudhary, Savita
    Bhasin, Aman K. K.
    Bhasin, Kuldip K.
    Coles, Simon J.
    Orton, James B.
    Isaia, Francesco
    Lippolis, Vito
    Pintus, Anna
    Slawin, Alexandra M. Z.
    Woollins, J. Derek
    Arca, Massimiliano
    CHEMISTRY-AN ASIAN JOURNAL, 2023, 18 (23)
  • [45] Synthesis, characterization and antibacterial activity of Pd(II), Pt(II) and Ag(I) complexes of 4-ethyl and 4-(p-tolyl)-1-(pyridin-2-yl)thiosemicarbazides
    El-Asmy, Ahmed A.
    Hassanian, Mohammad M.
    Abdel-Rhman, Mohammad H.
    JOURNAL OF SULFUR CHEMISTRY, 2010, 31 (02) : 141 - 151
  • [46] One-Pot Synthesis of New (1,3-Thiazolo[5,4-b]pyridin-2-yl)benzenediols and Their Antiproliferative Activities against Human Cancer Cell Lines
    Matysiak, Joanna
    Karpinska, Monika M.
    Niewiadomy, Andrzej
    Wietrzyk, Joanna
    Klopotowska, Dagmara
    CHEMISTRY & BIODIVERSITY, 2012, 9 (01) : 48 - 57
  • [47] Experimental and theoretical study on the reaction of N3-phenyl-(pyridin-2-yl)carbohydrazonamide with itaconic anhydride
    Modzelewska-Banachiewicz, Bozena
    Paprocka, Renata
    Mazur, Liliana
    Saczewski, Jaroslaw
    Kutkowska, Jolanta
    Stepien, Dorota K.
    Cyranski, Michal
    JOURNAL OF MOLECULAR STRUCTURE, 2012, 1022 : 211 - 219
  • [48] Production of enantiomerically pure (S)-phenyl(pyridin-2-yl)methanol with Lactobacillus paracasei BD101
    Sahin, Engin
    Serencam, Huseyin
    Dertli, Enes
    BIOCATALYSIS AND BIOTRANSFORMATION, 2019, 37 (06) : 448 - 454
  • [49] A Rare Structural Motif for a Luminescent Cu(I) Coordination Polymer with 3-(Pyridin-2-yl)triimidazotriazine
    Malpicci, Daniele
    Blasi, Delia
    Marinotto, Daniele
    Forni, Alessandra
    Cariati, Elena
    Lucenti, Elena
    Carlucci, Lucia
    CRYSTALS, 2023, 13 (01)
  • [50] Synthesis of Dihydropyran Derivatives and Evaluation of Their Antibacterial Activities
    Ding, Jiyu
    Wang, Cuiyun
    LATIN AMERICAN JOURNAL OF PHARMACY, 2016, 35 (03): : 625 - 628
12345