Bronchoprotective and bronchodilator effects of an HFA pMDI vs. a CFC pMDI and a DPI containing formoterol in asthma patients

被引：9

作者：

Langley, SJ ^{[1
]}

Houghton, CM ^{[1
]}

Singh, SD ^{[1
]}

机构：

[1] S Manchester Univ Hosp Trust, Wythenshawe Hosp, N W Lung Res Ctr, Med Evaluat Unit, Manchester M23 9LT, Lancs, England

来源：

RESPIRATION | 2005年 / 72卷

关键词：

formoterol; bronchoprotection; bronchodilation; hydrofluoroalkanes; pressurized metered-dose inhalers; dry powder inhalers; asthma;

D O I：

10.1159/000083691

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In this double-blind, placebo-controlled, crossover study we compared the bronchoprotective effects of formoterol 12 mu g inhaled via an HFA-134a inhaler (Modulite(R) HFA) versus a CFC and a DPI device in 38 patients with mild-to-moderate persistent asthma. All three formoterol preparations significantly increased methacholine PD20 and FEV1 and improved small airway function parameters compared with placebo ( p < 0.001). No significant differences were observed between formoterol formulations. In conclusion, Modulite(R) HFA formoterol was found to be an effective and well tolerated treatment in patients with asthma, with comparable efficacy to current formoterol preparations. Copyright (C) 2005 S. Karger AG, Basel.

引用

页码：35 / 37

页数：3

共 5 条

[1]

*BRIT THOR SOC, 2003, THORAX S1, V58

[2] Modulite®:: a means of designing the aerosols generated by pressurized metered dose inhalers [J].