Spliceosomal UsnRNP biogenesis, structure and function

被引：534
作者：
Will, CL [1 ]
Lührmann, R [1 ]
机构：
[1] Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
来源：
CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 03期
关键词：
D O I：
10.1016/S0955-0674(00)00211-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Significant advances have been made in elucidating the biogenesis pathway and three-dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6 . U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre-mRNA splicing has been presented.
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收藏
页码：290 / 301
页数：12
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