Ru(II)-Catalyzed C-H Activation Reaction between 2-Phenyl-quinazolinone and Vinylene Carbonate

被引：9

作者：

Chen, Yuncan ^{[1
,2
,3
]}

Huang, Xin ^{[2
,3
]}

Xu, Yingying ^{[2
,3
]}

Li, Jianglian ^{[2
,3
]}

Lai, Ruizhi ^{[2
,3
]}

Guan, Mei ^{[1
]}

Wu, Yong ^{[2
,3
]}

机构：

[1] Sichuan Univ, West China Hosp, 37 Guoxue Lane, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, 17 Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, Dept Med Chem, West China Sch Pharm, 17 Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China

来源：

SYNLETT | 2021年 / 32卷 / 19期

基金：

中国国家自然科学基金;

关键词：

C-H activation; ruthenium; annulation reaction; vinylene carbonate; quinazolinones; LUOTONIN-A; DERIVATIVES; EFFICIENT; ACTIVATION/ANNULATION; FUNCTIONALIZATION; QUINAZOLINONES; DIOLEFINATION; RUTAECARPINE; ALKYNES; ESTERS;

D O I：

10.1055/a-1608-5381

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the report, we described the ruthenium(II)-catalyzed C-H activation/cyclization of 2-arylquinazolinones with vinyl carbonate for the synthesis of different fused quinazolinones. Through this strategy, the 6-hydroxy-5,6-dihydro-8 H-isoquinolino[1,2-b]quinazolin-8-one and 8 H-isoquino[1,2-b] quinazolin-8-one have been obtained, respectively, under different temperatures. Additionally, the reaction features broad substrate scope and good yields, only producing carbon dioxide as byproduct. Moreover, we performed preliminary mechanistic studies of this reaction and proposed a possible mechanism.

引用

页码：1963 / 1968

页数：6

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