Circular RNAs as Promising Biomarkers: A Mini-Review

被引：72

作者：

Abu, Nadiah ^{[1
]}

Jamal, Rahman ^{[1
]}

机构：

[1] UKM, Med Ctr, UKM Med Mol Biol Inst, Kuala Lumpur, Malaysia

来源：

FRONTIERS IN PHYSIOLOGY | 2016年 / 7卷

关键词：

circular RNAs; cancer; biomarker; targeted therapies; PROFILING REVEALS; EXPRESSION; IDENTIFICATION; EXOSOMES; ABUNDANT; GROWTH; CANCER; DATABASE; MIR-7;

D O I：

10.3389/fphys.2016.00355

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The interest in circular RNAs has resurfaced in the past few years. What was considered as "junk" for nearly two decades is now one of the most interesting molecules. Circular RNAs are non-coding RNAs that are formed by back-splicing events and have covalently closed loops with no poly-adenylated tails. The regulation of circular RNAs is distinctive and they are selectively abundant in different types of tissues. Based on the current knowledge of circular RNAs, these molecules have the potential to be the "next big thing" especially as biomarkers for different diseases. This mini-review attempts to concisely look at the biology of circular RNAs, the putative functional activities, the prevalence of circular RNAs, and the possible role of circular RNA as biomarkers for diagnosis or measuring drug response.

引用

页数：6

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