Beneficial Effect of a Multistrain Synbiotic Prodefen® Plus on the Systemic and Vascular Alterations Associated with Metabolic Syndrome in Rats: The Role of the Neuronal Nitric Oxide Synthase and Protein Kinase A

被引：12

作者：

Llevenes, Pablo ^{[1
]}

Rodrigues-Diez, Raquel ^{[2
,3
,4
]}

Cros-Brunso, Laia ^{[1
]}

Isabel Prieto, Ma ^{[4
,5
]}

Casani, Laura ^{[6
,7
]}

Balfagon, Gloria ^{[1
,3
,4
]}

Blanco-Rivero, Javier ^{[1
,3
,4
]}

机构：

[1] Univ Autonoma Madrid, Sch Med, Dept Physiol, Calle Arzobispo Morcillo 4, Madrid 28029, Spain

[2] Univ Autonoma Madrid, Sch Med, Dept Pharmacol & Therapeut, Calle Arzobispo Morcillo 4, Madrid 28029, Spain

[3] Ctr Biomed Res Network CIBER Cardiovasc Dis, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain

[4] Univ Hosp la Paz IdIPaz, Res Inst, Calle Pedro Rico 6, Madrid 28029, Spain

[5] Hosp Univ la Paz, Dept Gen & Digest Surg, Paseo Castellana 261, Madrid 28046, Spain

[6] Res Inst Santa Creu, Carrer St Quinti 77-79, Barcelona 08041, Spain

[7] St Pau Hosp, Carrer St Quinti 77-79, Barcelona 08041, Spain

来源：

NUTRIENTS | 2020年 / 12卷 / 01期

关键词：

metabolic syndrome; synbiotic; hypertension; superior mesenteric artery; perivascular nitrergic innervation; nitric oxide; neuronal nitric oxide synthase; protein kinase a; DIET-INDUCED OBESITY; GUT MICROBIOTA; MESENTERIC-ARTERY; OXIDATIVE STRESS; INSULIN SENSITIVITY; EXPRESSION; PROBIOTICS; ALTERS; INNERVATION; IMPROVEMENT;

D O I：

10.3390/nu12010117

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

A high fat diet (HFD) intake is crucial for the development and progression of metabolic syndrome (MtS). Increasing evidence links gut dysbiosis with the metabolic and vascular alterations associated with MtS. Here we studied the use of a combination of various probiotic strains together with a prebiotic (synbiotic) in a commercially available Prodefen((R)) Plus. MtS was induced by HFD (45%) in male Wistar rats. Half of the MtS animals received Prodefen((R)) Plus for 4 weeks. At 12 weeks, we observed an increase in body weight, together with the presence of insulin resistance, liver steatosis, hypertriglyceridemia and hypertension in MtS rats. Prodefen((R)) Plus supplementation did not affect the body weight gain but ameliorated all the MtS-related symptoms. Moreover, the hypertension induced by HFD is caused by a diminished both nitric oxide (NO) functional role and release probably due to a diminished neuronal nitric oxide synthase (nNOS) activation by protein kinase A (PKA) pathway. Prodefen((R)) Plus supplementation for 4 weeks recovered the NO function and release and the systolic blood pressure was returned to normotensive values as a result. Overall, supplementation with Prodefen((R)) Plus could be considered an interesting non-pharmacological approach in MtS.

引用

页数：18