Is there such a thing as protocol immunosuppression in liver transplantation?

被引:6
|
作者
McCaughan, Geoffrey W. [1 ]
Sze, Kenny Ching Pan [1 ]
Strasser, Simone I. [2 ]
机构
[1] Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Sydney, NSW, Australia
[2] Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Camperdown, NSW 2050, Australia
关键词
hepatitis C; immunosuppression; liver transplantation; rejection; renal failure; HEPATITIS-C VIRUS; RENAL-INSUFFICIENCY; META-REGRESSION; DOUBLE-BLIND; RECIPIENTS; SIROLIMUS; TACROLIMUS; METAANALYSIS; AZATHIOPRINE; CYCLOSPORINE;
D O I
10.1586/17474124.2014.954550
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Protocol immunosuppression in liver transplantation is largely an outdated concept. Immunosuppression is now personalized to the individual patient on the basis of several factors including underlying etiology of original liver disease (e.g., HCV, hepatocellular carcinoma), renal function, metabolic co-morbidities and the patient's immunological state. These include omission of corticosteroids in HCV infection and those with major metabolic risk factors, the minimization of calcineurin inhibitors in the presence of renal dysfunction and the use of mTOR inhibitors in patients with malignancy. The basis for such decision-making is discussed in this editorial.
引用
收藏
页码:1 / 4
页数:4
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