Sprayable antibacterial Persian gum-silver nanoparticle dressing for wound healing acceleration

被引：41

作者：

Amirsadeghi, Armin ^{[1
,2
]}

Jafari, Arman ^{[1
]}

Hashemi, Seyyedeh-Sara ^{[2
]}

Kazemi, Aboozar ^{[3
]}

Ghasemi, Younes ^{[3
]}

Derakhshanfar, Amin ^{[4
,5
,6
]}

Shahbazi, Mohammad-Ali ^{[7
,8
]}

Niknezhad, Seyyed Vahid ^{[2
,3
]}

机构：

[1] Shiraz Univ, Sch Chem & Petr Engn, Shiraz 7134851154, Iran

[2] Shiraz Univ Med Sci, Burn & Wound Healing Res Ctr, Shiraz 713451978, Iran

[3] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz 713451583, Iran

[4] Shiraz Univ Med Sci, Sch Paramed Sci, Diagnost Lab Sci & Technol Res Ctr, Shiraz, Iran

[5] Shiraz Univ Med Sci, Dept Comparat Biomed Sci, Sch Adv Med Sci & Technol, Shiraz, Iran

[6] Shiraz Univ Med Sci, Comparat & Expt Med Ctr, Shiraz, Iran

[7] Univ Helsinki, Div Pharmaceut Chem & Technol, Drug Res Program, Fac Pharm, FI-00014 Helsinki, Finland

[8] Zanjan Univ Med Sci, Zanjan Pharmaceut Nanotechnol Res Ctr ZPNRC, Zanjan 4513956184, Iran

来源：

MATERIALS TODAY COMMUNICATIONS | 2021年 / 27卷

基金：

芬兰科学院;

关键词：

Persian gum; Nanoparticle; Antibacterial; Spray; Skin; Wound dressing; NANOFIBERS; HYDROGELS;

D O I：

10.1016/j.mtcomm.2021.102225

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Wound infection is considered a significant challenge in skin injuries. Sprayable antibacterial wound dressings are interesting alternatives to their traditional counterparts because of their facile preparation, ease-of-use, and the possibility of topical delivery of antibacterial materials. Herein, novel sprayable antibacterial dressings are formulated and reported. The dressings were developed by in-situ formation of Ag-nanoparticles (Ag-NPs) using Persian gum (PG) as a carbohydrate polymer. Several tests were conducted to investigate the effect of polymer concentration on the sprayablity, biocompatibility, and antibacterial activity of the dressings (PG/Ag-NPs). Results showed that formulations up to 2 wt.% PG/Ag-NPs could be sprayed properly and form intact films. Antibacterial evaluations also showed biocidal activity of 1% PG/Ag-NPs against Pseudomonas aeruginosa and Staphylococcus aureus. Cytotoxicity and in vivo full-thickness wound healing evaluation confirmed that 1% PG/ Ag-NPs spray was safe and improved wound healing process. All the results confirmed the high potential of formulated sprayable dressings for wound repair.

引用

页数：10

共 51 条

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