Easy synthesis of imidazo[1,5-a]indol-3-ones through Rh(iii)-catalyzed C-H allenylation/annulation

被引：19

作者：

Zhu, Bin ^{[1
]}

Yao, Zhenyu ^{[1
]}

Huang, Lang ^{[1
]}

Cui, Xiuling ^{[1
]}

机构：

[1] Huaqiao Univ, Key Lab Precis Med & Mol Diag Fujian Univ, Key Lab Xiamen Marine & Gene Drugs,Minist Educ, Engn Res Ctr Mol Med,Key Lab Fujian Mol Med,Sch B, Xiamen 361021, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 90期

关键词：

PROPARGYL ALCOHOLS; CARBENOID FUNCTIONALIZATION; DIRECTING GROUP; 4+1 ANNULATION; N BOND; ACTIVATION; BENZAMIDES; 2-ALKENYLPHENOLS; ISOINDOLINONES; CONSTRUCTION;

D O I：

10.1039/d1cc04359e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and regioselective synthesis of imidazo[1,5-a]indol-3-ones has been developed via a sequential C-H allenylation/annulation starting from easily available N-methoxycarbamoyl indoles and propargyl alcohols, in which the propargyl alcohols served as a C1 synthon. This strategy displays excellent regioselectivity, high atom economy and tolerates a broad substrate scope.

引用

页码：12012 / 12015

页数：4

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