Easy synthesis of imidazo[1,5-a]indol-3-ones through Rh(iii)-catalyzed C-H allenylation/annulation

被引：19
作者：
Zhu, Bin [1 ]
Yao, Zhenyu [1 ]
Huang, Lang [1 ]
Cui, Xiuling [1 ]
机构：
[1] Huaqiao Univ, Key Lab Precis Med & Mol Diag Fujian Univ, Key Lab Xiamen Marine & Gene Drugs,Minist Educ, Engn Res Ctr Mol Med,Key Lab Fujian Mol Med,Sch B, Xiamen 361021, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 90期
关键词：
PROPARGYL ALCOHOLS; CARBENOID FUNCTIONALIZATION; DIRECTING GROUP; 4+1 ANNULATION; N BOND; ACTIVATION; BENZAMIDES; 2-ALKENYLPHENOLS; ISOINDOLINONES; CONSTRUCTION;
D O I：
10.1039/d1cc04359e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient and regioselective synthesis of imidazo[1,5-a]indol-3-ones has been developed via a sequential C-H allenylation/annulation starting from easily available N-methoxycarbamoyl indoles and propargyl alcohols, in which the propargyl alcohols served as a C1 synthon. This strategy displays excellent regioselectivity, high atom economy and tolerates a broad substrate scope.
引用
收藏
页码：12012 / 12015
页数：4
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