RETRACTED: ATPase inhibitory factor 1 is a prognostic marker and contributes to proliferation and invasion of human gastric cancer cells (Retracted article. See vol. 160, 2023)

被引:29
|
作者
Yin, Tao [1 ]
Lu, Li [1 ]
Xiong, Zhiguo [1 ]
Wei, Shaozhong [1 ]
Cui, Diansheng [1 ]
机构
[1] Hubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R China
关键词
IF1; Gastric cancer; Prognosis; Tumor growth; Metastasis; EXPRESSION; SYNTHASE; FBXW7; IF1;
D O I
10.1016/j.biopha.2014.12.036
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
ATPase inhibitory factor 1 (IF1) has recently been considered as a potential oncogene in human cancers. Recently, increasing evidences have shown that IF1 is overexpressed in human cancers and promotes tumor growth and metastasis. In this study, we found that the expression levels of IF1 protein and mRNA in gastric cancer tissues were significantly higher than those in matched adjacent nontumor tissues. Clinical association analysis revealed that the positive expression of IF1 was correlated with large tumor size, lymph node metastasis, venous infiltration and advanced TNM tumor stage in gastric cancer. Furthermore, IF1 was an independent prognostic marker for predicting 5-year overall survival and disease-free survival of gastric cancer patients. In vitro studies found that IF1 knockdown significantly inhibited cell proliferation and induced apoptosis in SGC-7901 cells. In a nude mouse xenograft model, IF1 knockdown prominently slowed down tumor growth with reduced number of Ki-67 positive cancer cells and elevated number of TUNEL positive cancer cells. Otherwise, IF1 knockdown evidently reduced SGC-7901 cell migration and invasion. In conclusion, these results indicate that IF1 may serve as a prognostic marker and promotes tumor growth and metastasis in gastric cancer. (C) 2015 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:90 / 96
页数:7
相关论文
共 50 条
  • [1] RETRACTED: MTA1 promotes proliferation and invasion in human gastric cancer cells (Retracted article. See vol. 10, pg. 1519, 2017)
    Yao, Yuan
    Feng, Shuting
    Xiao, Mingming
    Li, Yan
    Yang, Li
    Gong, Jiao
    ONCOTARGETS AND THERAPY, 2015, 8 : 1785 - 1794
  • [2] RETRACTED: Silencing of SOX12 by shRNA suppresses migration, invasion and proliferation of breast cancer cells (Retracted article. See vol. 43, 2023)
    Ding, Hanzhi
    Quan, Hong
    Yan, Weiguo
    Han, Jing
    BIOSCIENCE REPORTS, 2016, 36
  • [3] RETRACTED: Scorpion venoms in gastric cancer (Retracted article. See vol. 20, 2020)
    Zhang, Xiao-Ying
    Zhang, Pei-Ying
    ONCOLOGY LETTERS, 2016, 12 (05) : 3683 - 3686
  • [4] RETRACTED: Ferroptosis in Macrophage Impairment in Sepsis (Retracted article. See vol. 2023, 2023)
    Liu, Hongxuan
    Li, Lei
    APPLIED BIONICS AND BIOMECHANICS, 2022, 2022
  • [5] RETRACTED: MicroRNA-874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin (Retracted article. See vol. 27, 2023)
    Zhang, Yongfeng
    Wang, Xueqin
    Zhao, Yuehua
    MOLECULAR MEDICINE REPORTS, 2018, 18 (03) : 3099 - 3105
  • [6] RETRACTED: An Eocene army ant (Retracted article. See vol. 19, 2023)
    Sosiak, Christine E.
    Borowiec, Marek L.
    Barden, Phillip
    BIOLOGY LETTERS, 2022, 18 (11)
  • [7] RETRACTED: MicroRNA-708 inhibits the proliferation and invasion of osteosarcoma cells by directly targeting ZEB1 (Retracted article. See vol. 27, 2023)
    He, Jun
    Xiang, Deng
    Lin, Yanshui
    MOLECULAR MEDICINE REPORTS, 2019, 19 (05) : 3948 - 3954
  • [8] RETRACTED: Knockdown of AQP1 inhibits growth and invasion of human ovarian cancer cells (Retracted article. See vol. 24, 2021)
    Wang, Yanli
    Fan, Yanyan
    Zheng, Chunhua
    Zhang, Xiaomeng
    MOLECULAR MEDICINE REPORTS, 2017, 16 (04) : 5499 - 5504
  • [9] RETRACTED: Electrochemical Preparation of Nanocatalysts and Their Application in Electrocatalysis (Retracted article. See vol. 2023, 2023)
    Zhou, Hao
    INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY, 2022, 2022
  • [10] RETRACTED: Driving Detection Based on the Multifeature Fusion (Retracted article. See vol. 2023, 2023)
    Yang, Qiufen
    Lu, Yan
    JOURNAL OF CONTROL SCIENCE AND ENGINEERING, 2022, 2022