RETRACTED: ATPase inhibitory factor 1 is a prognostic marker and contributes to proliferation and invasion of human gastric cancer cells (Retracted article. See vol. 160, 2023)
被引:29
|
作者:
Yin, Tao
论文数: 0引用数: 0
h-index: 0
机构:
Hubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R ChinaHubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R China
Yin, Tao
[1
]
Lu, Li
论文数: 0引用数: 0
h-index: 0
机构:
Hubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R ChinaHubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R China
Lu, Li
[1
]
Xiong, Zhiguo
论文数: 0引用数: 0
h-index: 0
机构:
Hubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R ChinaHubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R China
Xiong, Zhiguo
[1
]
Wei, Shaozhong
论文数: 0引用数: 0
h-index: 0
机构:
Hubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R ChinaHubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R China
Wei, Shaozhong
[1
]
Cui, Diansheng
论文数: 0引用数: 0
h-index: 0
机构:
Hubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R ChinaHubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R China
Cui, Diansheng
[1
]
机构:
[1] Hubei Canc Hosp, Dept Gastrointestinal Surg, Wuhan 430060, Peoples R China
ATPase inhibitory factor 1 (IF1) has recently been considered as a potential oncogene in human cancers. Recently, increasing evidences have shown that IF1 is overexpressed in human cancers and promotes tumor growth and metastasis. In this study, we found that the expression levels of IF1 protein and mRNA in gastric cancer tissues were significantly higher than those in matched adjacent nontumor tissues. Clinical association analysis revealed that the positive expression of IF1 was correlated with large tumor size, lymph node metastasis, venous infiltration and advanced TNM tumor stage in gastric cancer. Furthermore, IF1 was an independent prognostic marker for predicting 5-year overall survival and disease-free survival of gastric cancer patients. In vitro studies found that IF1 knockdown significantly inhibited cell proliferation and induced apoptosis in SGC-7901 cells. In a nude mouse xenograft model, IF1 knockdown prominently slowed down tumor growth with reduced number of Ki-67 positive cancer cells and elevated number of TUNEL positive cancer cells. Otherwise, IF1 knockdown evidently reduced SGC-7901 cell migration and invasion. In conclusion, these results indicate that IF1 may serve as a prognostic marker and promotes tumor growth and metastasis in gastric cancer. (C) 2015 Elsevier Masson SAS. All rights reserved.
机构:
Tongji Univ, Sch Med, Dept Breast Surg, Shanghai East Hosp, Shanghai 200120, Peoples R ChinaTongji Univ, Sch Med, Dept Breast Surg, Shanghai East Hosp, Shanghai 200120, Peoples R China
Ding, Hanzhi
Quan, Hong
论文数: 0引用数: 0
h-index: 0
机构:
Tongji Univ, Sch Med, Dept Breast Surg, Shanghai East Hosp, Shanghai 200120, Peoples R ChinaTongji Univ, Sch Med, Dept Breast Surg, Shanghai East Hosp, Shanghai 200120, Peoples R China
Quan, Hong
Yan, Weiguo
论文数: 0引用数: 0
h-index: 0
机构:
Tongji Univ, Sch Med, Dept Breast Surg, Shanghai East Hosp, Shanghai 200120, Peoples R ChinaTongji Univ, Sch Med, Dept Breast Surg, Shanghai East Hosp, Shanghai 200120, Peoples R China
Yan, Weiguo
Han, Jing
论文数: 0引用数: 0
h-index: 0
机构:
Tongji Univ, Sch Med, Dept Breast Surg, Shanghai East Hosp, Shanghai 200120, Peoples R ChinaTongji Univ, Sch Med, Dept Breast Surg, Shanghai East Hosp, Shanghai 200120, Peoples R China
机构:
Nanjing Univ Chinese Med, Inst Informat, Nanjing 221009, Jiangsu, Peoples R ChinaNanjing Univ Chinese Med, Inst Informat, Nanjing 221009, Jiangsu, Peoples R China
Zhang, Xiao-Ying
Zhang, Pei-Ying
论文数: 0引用数: 0
h-index: 0
机构:
Southeast Univ, Dept Cardiol, Xuzhou Cent Hosp, Affiliated Xuzhou Hosp,Med Coll, 199 South Jiefang Rd, Xuzhou 221009, Jiangsu, Peoples R ChinaNanjing Univ Chinese Med, Inst Informat, Nanjing 221009, Jiangsu, Peoples R China
机构:
Weifang Med Univ, Affiliated Hosp, Dept Pediat, Weifang 261031, Shandong, Peoples R ChinaWeifang Med Univ, Affiliated Hosp, Dept Pediat, Weifang 261031, Shandong, Peoples R China
Zhang, Yongfeng
Wang, Xueqin
论文数: 0引用数: 0
h-index: 0
机构:
Weifang Med Univ, Affiliated Hosp, Med Imaging Ctr, 2428 Yuhe Rd, Weifang 261031, Shandong, Peoples R ChinaWeifang Med Univ, Affiliated Hosp, Dept Pediat, Weifang 261031, Shandong, Peoples R China
Wang, Xueqin
Zhao, Yuehua
论文数: 0引用数: 0
h-index: 0
机构:
Weifang Med Univ, Affiliated Hosp, Dept Pediat, Weifang 261031, Shandong, Peoples R ChinaWeifang Med Univ, Affiliated Hosp, Dept Pediat, Weifang 261031, Shandong, Peoples R China
机构:
New Jersey Inst Technol, Federated Dept Biol Sci, Newark, NJ 07102 USANew Jersey Inst Technol, Federated Dept Biol Sci, Newark, NJ 07102 USA
Sosiak, Christine E.
Borowiec, Marek L.
论文数: 0引用数: 0
h-index: 0
机构:
Colorado State Univ, Dept Agr Biol, Ft Collins, CO 80523 USA
Colorado State Univ, CP Gillette Museum Arthropod Divers, Ft Collins, CO 80523 USANew Jersey Inst Technol, Federated Dept Biol Sci, Newark, NJ 07102 USA
Borowiec, Marek L.
Barden, Phillip
论文数: 0引用数: 0
h-index: 0
机构:
New Jersey Inst Technol, Federated Dept Biol Sci, Newark, NJ 07102 USA
Amer Museum Nat Hist, Div Invertebrate Zool, New York, NY 10024 USANew Jersey Inst Technol, Federated Dept Biol Sci, Newark, NJ 07102 USA