Antiplatelet Therapy, Platelet Function Testing, and Bleeding Complications in Cardiac Surgery Patients

被引：6

作者：

Hansson, Emma C. ^{[1
,2
]}

Jeppsson, Anders ^{[1
,2
]}

机构：

[1] Sahlgrens Univ Hosp, Dept Cardiothorac Surg, S-41345 Gothenburg, Sweden

[2] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2017年 / 43卷 / 07期

关键词：

antiplatelet therapy; acetylsalicylic acid; P2Y(12) inhibitors; bleeding; coronary artery bypass grafting; platelet function testing; ACUTE CORONARY SYNDROMES; ACUTE MYOCARDIAL-INFARCTION; ARTERY-BYPASS SURGERY; BLOOD-TRANSFUSION; UNSTABLE ANGINA; CLOPIDOGREL; TICAGRELOR; ASPIRIN; INHIBITION; MORTALITY;

D O I：

10.1055/s-0037-1603366

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antiplatelet therapy with acetylsalicylic acid, alone or in combination with a P2Y(12) inhibitor, reduces thromboembolic events in patients with coronary artery disease but increases the risk for spontaneous and perioperative bleeding complications. Both the antiplatelet effect and the risk for bleeding complications are larger with the new generation P2Y(12) inhibitors prasugrel and ticagrelor than with clopidogrel. In this review, the perioperative handling of acetylsalicylic acid and the P2Y(12) inhibitors clopidogrel, prasugrel, and ticagrelor will be discussed. In addition, the concept of platelet function testing in the surgical setting will be covered.

引用

页码：699 / 705

页数：7

共 46 条

[1] Bridging Antiplatelet Therapy With Cangrelor in Patients Undergoing Cardiac Surgery A Randomized Controlled Trial [J].

Angiolillo, Dominick J. ;

Firstenberg, Michael S. ;

Price, Matthew J. ;

Tummala, Pradyumna E. ;

Hutyra, Martin ;

Welsby, Ian J. ;

Voeltz, Michele D. ;

Chandna, Harish ;

Ramaiah, Chandrashekhar ;

Brtko, Miroslav ;

Cannon, Louis ;

Dyke, Cornelius ;

Liu, Tiepu ;

Montalescot, Gilles ;

Manoukian, Steven V. ;

Prats, Jayne ;

Topol, Eric J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (03) :265-274

[2] Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial [J].

Becker, Richard C. ;

Bassand, Jean Pierre ;

Budaj, Andrzej ;

Wojdyla, Daniel M. ;

James, Stefan K. ;

Cornel, Jan H. ;

French, John ;

Held, Claes ;

Horrow, Jay ;

Husted, Steen ;

Lopez-Sendon, Jose ;

Lassila, Riitta ;

Mahaffey, Kenneth W. ;

Storey, Robert F. ;

Harrington, Robert A. ;

Wallentin, Lars .

EUROPEAN HEART JOURNAL, 2011, 32 (23) :2933-2944

[3] EFFECT OF ADENOSINE DIPHOSPHATE ON CONCENTRATION OF PLATELETS IN CIRCULATING BLOOD [J].

BORN, GVR ;

CROSS, MJ .

NATURE, 1963, 197 (487) :974-&

[4] Structural and functional characterization of a specific antidote for ticagrelor [J].

Buchanan, Andrew ;

Newton, Philip ;

Pehrsson, Susanne ;

Inghardt, Tord ;

Antonsson, Thomas ;

Svensson, Peder ;

Sjogren, Tove ;

Oster, Linda ;

Janefeldt, Annika ;

Sandinge, Ann-Sofie ;

Keyes, Feenagh ;

Austin, Mark ;

Spooner, Jennifer ;

Gennemark, Peter ;

Penney, Mark ;

Howells, Garnet ;

Vaughan, Tristan ;

Nylander, Sven .

BLOOD, 2015, 125 (22) :3484-3490

[5] The role of point-of-care platelet function testing in predicting postoperative bleeding following cardiac surgery: a systematic review and meta-analysis [J].

Corredor, C. ;

Wasowicz, M. ;

Karkouti, K. ;

Sharma, V. .

ANAESTHESIA, 2015, 70 (06) :715-731

[6] Dual Anti-platelet Therapy After Coronary Artery Bypass Grafting: Is There Any Benefit? A Systematic Review and Meta-Analysis [J].

Deo, Salil V. ;

Dunlay, Shannon M. ;

Shah, Ishan K. ;

Altarabsheh, Salah E. ;

Erwin, Patricia J. ;

Boilson, Barry A. ;

Park, Soon J. ;

Joyce, Lyle D. .

JOURNAL OF CARDIAC SURGERY, 2013, 28 (02) :109-116

[7] The association of blood transfusion with mortality after cardiac surgery: cause or confounding? (CME) [J].

Dixon, Barry ;

Santamaria, John D. ;

Reid, David ;

Collins, Marnie ;

Rechnitzer, Thomas ;

Newcomb, Andrew E. ;

Nixon, Ian ;

Yii, Michael ;

Rosalion, Alexander ;

Campbell, Duncan J. .

TRANSFUSION, 2013, 53 (01) :19-27

[8] Universal definition of perioperative bleeding in adult cardiac surgery [J].

Dyke, Cornelius ;

Aronson, Solomon ;

Dietrich, Wulf ;

Hofmann, Axel ;

Karkouti, Keyvan ;

Levi, Marcel ;

Murphy, Gavin J. ;

Sellke, Frank W. ;

Shore-Lesserson, Linda ;

von Heymann, Christian ;

Ranucci, Marco .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2014, 147 (05) :1458-+

[9] Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical Revascularization for non-ST-elevation acute coronary syndrome - The Clopidogrel in Unstable Angina to prevent Recurrent Ischemic Events (CURE) trial [J].

Fox, KAA ;

Mehta, SR ;

Peters, R ;

Zhao, F ;

Lakkis, N ;

Gersh, BJ ;

Yusuf, S .

CIRCULATION, 2004, 110 (10) :1202-1208

[10] Reexploration for Bleeding and Its Association With Mortality After Cardiac Surgery [J].

Frojd, Victoria ;

Jeppsson, Anders ;

Ranucci, Marco .

ANNALS OF THORACIC SURGERY, 2016, 102 (01) :109-117

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