Lysophosphatidic Acid Signaling in the Nervous System

被引：222

作者：

Yung, Yun C. ^{[1
]}

Stoddard, Nicole C. ^{[1
,2
]}

Mirendil, Hope ^{[1
]}

Chun, Jerold ^{[1
]}

机构：

[1] Scripps Res Inst, Mol & Cellular Neurosci Dept, Dorris Neurosci Ctr, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Sch Med, Biomed Sci Grad Program, La Jolla, CA 92037 USA

来源：

NEURON | 2015年 / 85卷 / 04期

关键词：

INDUCED NEURITE RETRACTION; RECEPTOR-DEFICIENT MICE; HUMAN ENDOTHELIAL-CELLS; PHOSPHOLIPASE A(2); NEUROPATHIC PAIN; GENE-EXPRESSION; LPA RECEPTORS; VASCULAR DEVELOPMENT; LYSOPHOSPHOLIPASE-D; BARRIER FUNCTION;

D O I：

10.1016/j.neuron.2015.01.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The brain is composed of many lipids with varied forms that serve not only as structural components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an important bioactive lipid species that is part of the lysophospholipid (LP) family. LPA is primarily derived from membrane phospholipids and signals through six cognate G protein-coupled receptors (GPCRs), LPA(1-6). These receptors are expressed on most cell types within central and peripheral nervous tissues and have been functionally linked to many neural processes and pathways. This Review covers a current understanding of LPA signaling in the nervous system, with particular focus on the relevance of LPA to both physiological and diseased states.

引用

页码：669 / 682

页数：14

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