Adipocyte fatty acid binding protein in OVA-induced asthmatic mice

被引：0
|
作者：
An, Shuhua [1 ]
Zheng, Bojuan [1 ]
Li, Jinying [1 ]
Li, Quanheng [1 ]
Zhang, Lianshan [2 ]
Sun, Junfeng [1 ]
机构：
[1] Childrens Hosp Hebei Prov, Dept Resp 1, 133 Jianhua South St, Shijiazhuang 050031, Peoples R China
[2] Hebei Med Univ, Dept Pathol, Shijiazhuang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2016年 / 9卷 / 07期
关键词：
Asthma; A-FABP; mice; ADIPOSE-TISSUE; CELL-FUNCTION; ATHEROSCLEROSIS; METABOLISM; AP2;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: To investigate the expression of adipocyte fatty acid binding protein (A-FABP) in OVA-induced asthmatic mice. Methods: Healthy female BALB/c mice were randomly divided into control group and asthma group. A-FABP in lung tissues was located using immunohistochemical staining and quantified by Western blot. A-FABP in serum was quantified by ELISA. Results: A-FABP mainly expressed in the cytoplasm of airway epithelial cells (AECs), macrophages and vessel endothelial cells (VECs). The expression of A-FABP was significantly higher in asthma group than control group (P<0.05). Conclusion: A-FABP might be involved in the pathophysiological process of asthma.
引用
收藏
页码：7365 / 7369
页数：5
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